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Intravenous maintenance fluid therapy in acutely and critically ill children: state of the evidence.
Brossier DW, Goyer I, Verbruggen SCAT, Jotterand Chaparro C, Rooze S, Marino LV, Schlapbach LJ, Tume LN, Valla FV; European Society of Paediatric and Neonatal Intensive Care-IV-MFT group. Brossier DW, et al. Lancet Child Adolesc Health. 2024 Mar;8(3):236-244. doi: 10.1016/S2352-4642(23)00288-2. Epub 2024 Jan 12. Lancet Child Adolesc Health. 2024. PMID: 38224704 Review.
IV-MFT is not typically treated in the same way as drugs with specific indications, contraindications, compositions, and associated adverse effects. ...
IV-MFT is not typically treated in the same way as drugs with specific indications, contraindications, compositions, and associated a …
Anti-Glomerular Basement Membrane Disease: Recent Updates.
Bharati J, Jhaveri KD, Salama AD, Oni L. Bharati J, et al. Adv Kidney Dis Health. 2024 May;31(3):206-215. doi: 10.1053/j.akdh.2024.04.007. Adv Kidney Dis Health. 2024. PMID: 39004460 Free article. Review.
Atypical forms of the disease are reported along with preceding triggers, such as immune checkpoint inhibitors, immunomodulatory drugs, and vaccines. Kidney outcomes in anti-glomerular basement membrane disease remain poor despite significant improvement in patient surviva …
Atypical forms of the disease are reported along with preceding triggers, such as immune checkpoint inhibitors, immunomodulatory drugs …
Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease.
Hey JA, Abushakra S, Blennow K, Reiman EM, Hort J, Prins ND, Sheardova K, Kesslak P, Shen L, Zhu X, Albayrak A, Paul J, Schaefer JF, Power A, Tolar M. Hey JA, et al. Drugs. 2024 Jul;84(7):811-823. doi: 10.1007/s40265-024-02067-8. Epub 2024 Jun 20. Drugs. 2024. PMID: 38902571 Free PMC article. Clinical Trial.
1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study.
Leavy OC, Russell RJ, Harrison EM, Lone NI, Kerr S, Docherty AB, Sheikh A, Richardson M, Elneima O, Greening NJ, Harris VC, Houchen-Wolloff L, McAuley HJC, Saunders RM, Sereno M, Shikotra A, Singapuri A, Aul R, Beirne P, Bolton CE, Brown JS, Choudhury G, Diar Bakerly N, Easom N, Echevarria C, Fuld J, Hart N, Hurst JR, Jones M, Parekh D, Pfeffer P, Rahman NM, Rowland-Jones S, Shah AM, Wootton DG, Jolley C, Thompson AAR, Chalder T, Davies MJ, De Soyza A, Geddes JR, Greenhalf W, Heller S, Howard L, Jacob J, Jenkins RG, Lord JM, Man WD, McCann GP, Neubauer S, Openshaw PJM, Porter J, Rowland MJ, Scott JT, Semple MG, Singh SJ, Thomas D, Toshner M, Lewis K, Heaney LG, Briggs A, Zheng B, Thorpe M, Quint JK, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Raman B, Wain LV, Brightling CE, Evans RA. Leavy OC, et al. ERJ Open Res. 2024 Sep 30;10(5):00474-2024. doi: 10.1183/23120541.00474-2024. eCollection 2024 Sep. ERJ Open Res. 2024. PMID: 39351379 Free PMC article.
Analysis of Cerebrospinal Fluid, Plasma β-Amyloid Biomarkers, and Cognition from a 2-Year Phase 2 Trial Evaluating Oral ALZ-801/Valiltramiprosate in APOE4 Carriers with Early Alzheimer's Disease Using Quantitative Systems Pharmacology Model.
Hey JA, Yu JY, Abushakra S, Schaefer JF, Power A, Kesslak P, Tolar M. Hey JA, et al. Drugs. 2024 Jul;84(7):825-839. doi: 10.1007/s40265-024-02068-7. Epub 2024 Jun 20. Drugs. 2024. PMID: 38902572 Free PMC article. Clinical Trial.
How to follow the guidelines, when the appropriate fluid is missing?
Brossier DW, Goyer I, Morice C, Alsohime F, Mayberry HF, Porcheret F, Tume LN, Valla FV; European Society of Pediatric and Neonatal Intensive Care (ESPNIC) IVMFT group. Brossier DW, et al. Eur J Pediatr. 2024 Jun;183(6):2797-2803. doi: 10.1007/s00431-024-05514-6. Epub 2024 Mar 18. Eur J Pediatr. 2024. PMID: 38498239 Free PMC article.
APOLLOE4 Phase 3 study of oral ALZ-801/valiltramiprosate in APOE ε4/ε4 homozygotes with early Alzheimer's disease: Trial design and baseline characteristics.
Abushakra S, Porsteinsson AP, Sabbagh M, Watson D, Power A, Liang E, MacSweeney E, Boada M, Flint S, McLaine R, Kesslak JP, Hey JA, Tolar M. Abushakra S, et al. Alzheimers Dement (N Y). 2024 Aug 13;10(3):e12498. doi: 10.1002/trc2.12498. eCollection 2024 Jul-Sep. Alzheimers Dement (N Y). 2024. PMID: 39144121 Free PMC article.
RESULTS: The APOLLOE4 Phase 3 trial enrolled 325 subjects with a mean age of 69 years, 51% female, MMSE 25.6, and 65% mild cognitive impairment. Topline results are expected in 2024. DISCUSSION: APOLLOE4 is the first disease-modification AD trial focused on APOE epsilon4/e …
RESULTS: The APOLLOE4 Phase 3 trial enrolled 325 subjects with a mean age of 69 years, 51% female, MMSE 25.6, and 65% mild cognitive impairm …
Nanostructured mesoporous silica carriers for platinum-based conjugates with anti-inflammatory agents.
Predarska I, Kaluđerović GN, Hey-Hawkins E. Predarska I, et al. Biomater Adv. 2024 Dec;165:213998. doi: 10.1016/j.bioadv.2024.213998. Epub 2024 Aug 19. Biomater Adv. 2024. PMID: 39236581 Free article. Review.
These agents are combined with platinum(II)-based antitumor drugs to create multifunctional platinum(IV) prodrugs, allowing for simultaneous delivery to tumor cells in a specific ratio. ...
These agents are combined with platinum(II)-based antitumor drugs to create multifunctional platinum(IV) prodrugs, allowing for simul …
Effect of salting and dehydration treatments on the physicochemical and gel properties of hen and duck egg yolks, plasma and granules.
Su Y, Sun Y, Chang C, Li J, Cai Y, Zhao Q, Huang Z, Xiong W, Gu L, Yang Y. Su Y, et al. J Sci Food Agric. 2024 Aug 15;104(10):6070-6084. doi: 10.1002/jsfa.13434. Epub 2024 Mar 27. J Sci Food Agric. 2024. PMID: 38441435
The changes in the pickling process of hen egg yolks (HEY) and duck egg yolks (DEY) plasma and granules were compared to reveal the gelation mechanism and the underlying causes of quality differences in salted HEY and DEY. Salted HEY can be compared with the …
The changes in the pickling process of hen egg yolks (HEY) and duck egg yolks (DEY) plasma and granules were compared to reveal the g …
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