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Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers - a European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study.
Richert L, Abadie C, Bonet A, Heyd B, Mantion G, Alexandre E, Bachellier P, Kingston S, Pattenden C, Illouz S, Dennison A, Hoffmann S, Coecke S. Richert L, et al. Among authors: heyd b. Toxicol In Vitro. 2010 Feb;24(1):335-45. doi: 10.1016/j.tiv.2009.05.022. Epub 2009 Jun 2. Toxicol In Vitro. 2010. PMID: 19497361
Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures.
Pekthong D, Blanchard N, Abadie C, Bonet A, Heyd B, Mantion G, Berthelot A, Richert L, Martin H. Pekthong D, et al. Among authors: heyd b. Chem Biol Interact. 2009 May 15;179(2-3):247-55. doi: 10.1016/j.cbi.2008.10.054. Epub 2008 Nov 8. Chem Biol Interact. 2009. PMID: 19041297
Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating.
Richert L, Liguori MJ, Abadie C, Heyd B, Mantion G, Halkic N, Waring JF. Richert L, et al. Among authors: heyd b. Drug Metab Dispos. 2006 May;34(5):870-9. doi: 10.1124/dmd.105.007708. Epub 2006 Feb 10. Drug Metab Dispos. 2006. PMID: 16473918
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