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Activated hepatic stellate cells mediate the differentiation of macrophages.
Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, Hibi T. Chang J, et al. Hepatol Res. 2013 Jun;43(6):658-69. doi: 10.1111/j.1872-034X.2012.01111.x. Epub 2012 Oct 29. Hepatol Res. 2013. PMID: 23107150
Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T. Okazawa A, et al. Am J Gastroenterol. 2002 Dec;97(12):3108-17. doi: 10.1111/j.1572-0241.2002.07107.x. Am J Gastroenterol. 2002. PMID: 12492197
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M. Ishikura T, et al. J Gastroenterol Hepatol. 2003 Aug;18(8):960-9. doi: 10.1046/j.1440-1746.2003.03097.x. J Gastroenterol Hepatol. 2003. PMID: 12859727
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M. Kanai T, et al. Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):131-6. doi: 10.2174/1568010033484250. Curr Drug Targets Inflamm Allergy. 2003. PMID: 14561165 Review.
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