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N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.
Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA. Ofengeim D, et al. Among authors: hickman ja. Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054. Nat Neurosci. 2012. PMID: 22366758 Free PMC article.
Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.
Jonas EA, Hoit D, Hickman JA, Brandt TA, Polster BM, Fannjiang Y, McCarthy E, Montanez MK, Hardwick JM, Kaczmarek LK. Jonas EA, et al. Among authors: hickman ja. J Neurosci. 2003 Sep 10;23(23):8423-31. doi: 10.1523/JNEUROSCI.23-23-08423.2003. J Neurosci. 2003. PMID: 12968005 Free PMC article.
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.
Li H, Chen Y, Jones AF, Sanger RH, Collis LP, Flannery R, McNay EC, Yu T, Schwarzenbacher R, Bossy B, Bossy-Wetzel E, Bennett MV, Pypaert M, Hickman JA, Smith PJ, Hardwick JM, Jonas EA. Li H, et al. Among authors: hickman ja. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2169-74. doi: 10.1073/pnas.0711647105. Epub 2008 Feb 4. Proc Natl Acad Sci U S A. 2008. PMID: 18250306 Free PMC article.
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals.
Jonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, Fannjiang Y, Ivanovska I, Basañez G, Kinnally KW, Zimmerberg J, Hardwick JM, Kaczmarek LK. Jonas EA, et al. Among authors: hickman ja. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13590-5. doi: 10.1073/pnas.0401372101. Epub 2004 Sep 1. Proc Natl Acad Sci U S A. 2004. PMID: 15342906 Free PMC article.
Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.
Gautier F, Guillemin Y, Cartron PF, Gallenne T, Cauquil N, Le Diguarher T, Casara P, Vallette FM, Manon S, Hickman JA, Geneste O, Juin P. Gautier F, et al. Among authors: hickman ja. Mol Cell Biol. 2011 Feb;31(4):832-44. doi: 10.1128/MCB.00161-10. Epub 2010 Dec 20. Mol Cell Biol. 2011. PMID: 21173168 Free PMC article.
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: hickman ja. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111
209 results