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NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells.
Espinosa A, García A, Härtel S, Hidalgo C, Jaimovich E. Espinosa A, et al. J Biol Chem. 2009 Jan 23;284(4):2568-75. doi: 10.1074/jbc.M804249200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028699
Additionally, both protein kinase C and phosphatidylinositol 3-kinase are presumably involved in insulin-induced ROS generation because bisindolylmaleimide, a nonspecific protein kinase C inhibitor, and LY290042, an inhibitor of phosphatidylinositol 3-kinase, inhibi …
Additionally, both protein kinase C and phosphatidylinositol 3-kinase are presumably involved in insulin-induced ROS generation becau …
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K.
Bruna B, Lobos P, Herrera-Molina R, Hidalgo C, Paula-Lima A, Adasme T. Bruna B, et al. Biochem Biophys Res Commun. 2018 Oct 20;505(1):201-207. doi: 10.1016/j.bbrc.2018.09.080. Epub 2018 Sep 19. Biochem Biophys Res Commun. 2018. PMID: 30243728
Calcium Rules.
Hidalgo C. Hidalgo C. Circulation. 2017 Apr 11;135(15):1379-1381. doi: 10.1161/CIRCULATIONAHA.117.024244. Circulation. 2017. PMID: 28396374 No abstract available.
Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors.
Llanos P, Contreras-Ferrat A, Barrientos G, Valencia M, Mears D, Hidalgo C. Llanos P, et al. PLoS One. 2015 Jun 5;10(6):e0129238. doi: 10.1371/journal.pone.0129238. eCollection 2015. PLoS One. 2015. PMID: 26046640 Free PMC article.
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation.
Adasme T, Haeger P, Paula-Lima AC, Espinoza I, Casas-Alarcón MM, Carrasco MA, Hidalgo C. Adasme T, et al. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3029-34. doi: 10.1073/pnas.1013580108. Epub 2011 Jan 31. Proc Natl Acad Sci U S A. 2011. PMID: 21282625 Free PMC article.
Additionally, incubation with BDNF enhanced the expression of RyR2, RyR3, and PKMζ, an atypical protein kinase C isoform with key roles in hippocampal memory consolidation. ...
Additionally, incubation with BDNF enhanced the expression of RyR2, RyR3, and PKMζ, an atypical protein kinase C isoform with key rol …
High-frequency field stimulation of primary neurons enhances ryanodine receptor-mediated Ca2+ release and generates hydrogen peroxide, which jointly stimulate NF-κB activity.
Riquelme D, Alvarez A, Leal N, Adasme T, Espinoza I, Valdés JA, Troncoso N, Hartel S, Hidalgo J, Hidalgo C, Carrasco MA. Riquelme D, et al. Antioxid Redox Signal. 2011 Apr 1;14(7):1245-59. doi: 10.1089/ars.2010.3238. Epub 2010 Sep 13. Antioxid Redox Signal. 2011. PMID: 20836702
Field stimulation also enhanced nuclear translocation of the NF-κB p65 protein and NF-κB -dependent transcription, and increased c-fos mRNA and type-2 RyR protein content. ...
Field stimulation also enhanced nuclear translocation of the NF-κB p65 protein and NF-κB -dependent transcription, and increased c-fo …
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells.
Muñoz P, Zavala G, Castillo K, Aguirre P, Hidalgo C, Núñez MT. Muñoz P, et al. Biol Res. 2006;39(1):189-90. doi: 10.4067/s0716-97602006000100021. Biol Res. 2006. PMID: 16629179
The ryanodine receptors Ca2+ release channels: cellular redox sensors?
Hidalgo C, Donoso P, Carrasco MA. Hidalgo C, et al. IUBMB Life. 2005 Apr-May;57(4-5):315-22. doi: 10.1080/15216540500092328. IUBMB Life. 2005. PMID: 16036616 Review.
Redox regulation of calcium release in skeletal and cardiac muscle.
Hidalgo C, Aracena P, Sanchez G, Donoso P. Hidalgo C, et al. Biol Res. 2002;35(2):183-93. doi: 10.4067/s0716-97602002000200009. Biol Res. 2002. PMID: 12415735
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