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The differentiating and apoptotic effects of 2-aza-5'-deoxycytidine are dependent on the PU.1 expression level in PU.1-transgenic K562 cells.
Aoyama S, Nakano H, Danbara M, Higashihara M, Harigae H, Takahashi S. Aoyama S, et al. Biochem Biophys Res Commun. 2012 Apr 20;420(4):775-81. doi: 10.1016/j.bbrc.2012.03.071. Epub 2012 Mar 20. Biochem Biophys Res Commun. 2012. PMID: 22459451
Therapeutic concentrations (0.1 and 0.5 μM) of 5-azadc resulted in growth arrest in the G2/M phase. Strikingly, however, K562 PU.1OE cells had significantly increased rates of G2/M and apoptotic sub-G1 phase cells. We observed the induction of cyclin B1, a regulator …
Therapeutic concentrations (0.1 and 0.5 μM) of 5-azadc resulted in growth arrest in the G2/M phase. Strikingly, however, K562 PU.1OE …
Ets-1 activates overexpression of JunB and CD30 in Hodgkin's lymphoma and anaplastic large-cell lymphoma.
Watanabe M, Itoh K, Togano T, Kadin ME, Watanabe T, Higashihara M, Horie R. Watanabe M, et al. Am J Pathol. 2012 Feb;180(2):831-8. doi: 10.1016/j.ajpath.2011.10.007. Epub 2011 Nov 19. Am J Pathol. 2012. PMID: 22107829 Free PMC article.
TRAF activation of C/EBPbeta (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages.
Horie R, Ishida T, Maruyama-Nagai M, Ito K, Watanabe M, Yoneyama A, Higashihara M, Kimura S, Watanabe T. Horie R, et al. Microbes Infect. 2007 May;9(6):721-8. doi: 10.1016/j.micinf.2007.02.017. Epub 2007 Feb 24. Microbes Infect. 2007. PMID: 17409010
Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma.
Watanabe M, Ogawa Y, Itoh K, Koiwa T, Kadin ME, Watanabe T, Okayasu I, Higashihara M, Horie R. Watanabe M, et al. Lab Invest. 2008 Jan;88(1):48-57. doi: 10.1038/labinvest.3700696. Epub 2007 Oct 29. Lab Invest. 2008. PMID: 17965727
Accumulation of allo-MHC cross-reactive memory T cells in bone marrow.
Hayama M, Shinohara N, Higashihara M, Eshima K. Hayama M, et al. Immunol Lett. 2008 May 15;117(2):154-60. doi: 10.1016/j.imlet.2008.01.005. Epub 2008 Feb 7. Immunol Lett. 2008. PMID: 18321597
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma.
Watanabe M, Sasaki M, Itoh K, Higashihara M, Umezawa K, Kadin ME, Abraham LJ, Watanabe T, Horie R. Watanabe M, et al. Cancer Res. 2005 Sep 1;65(17):7628-34. doi: 10.1158/0008-5472.CAN-05-0925. Cancer Res. 2005. PMID: 16140928
AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.
Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Abraham LJ, Watanabe T, Horie R. Watanabe M, et al. Am J Pathol. 2003 Aug;163(2):633-41. doi: 10.1016/S0002-9440(10)63690-5. Am J Pathol. 2003. PMID: 12875982 Free PMC article.
Signal transduction through mu kappa B-cell receptors expressed on pre-B cells is different from that through B-cell receptors on mature B cells.
Nakamura T, Koyama M, Yoneyama A, Higashihara M, Kawakami T, Yamamura H, Sada K, Okumura K, Kurokawa K. Nakamura T, et al. Immunology. 1996 Aug;88(4):593-9. doi: 10.1046/j.1365-2567.1996.d01-681.x. Immunology. 1996. PMID: 8881762 Free PMC article.
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