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Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.
Shimizu H, Yisireyili M, Higashiyama Y, Nishijima F, Niwa T. Shimizu H, et al. Among authors: higashiyama y. Life Sci. 2013 Feb 7;92(2):143-8. doi: 10.1016/j.lfs.2012.11.012. Epub 2012 Nov 28. Life Sci. 2013. PMID: 23201429
CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.
Shimizu H, Saito S, Higashiyama Y, Nishijima F, Niwa T. Shimizu H, et al. Among authors: higashiyama y. Am J Physiol Cell Physiol. 2013 Apr 1;304(7):C685-92. doi: 10.1152/ajpcell.00236.2012. Epub 2013 Feb 13. Am J Physiol Cell Physiol. 2013. PMID: 23407882
Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells.
Shimizu H, Bolati D, Higashiyama Y, Nishijima F, Shimizu K, Niwa T. Shimizu H, et al. Among authors: higashiyama y. Life Sci. 2012 Apr 9;90(13-14):525-30. doi: 10.1016/j.lfs.2012.01.013. Epub 2012 Feb 1. Life Sci. 2012. PMID: 22326498
Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.
Shimizu H, Bolati D, Adijiang A, Adelibieke Y, Muteliefu G, Enomoto A, Higashiyama Y, Higuchi Y, Nishijima F, Niwa T. Shimizu H, et al. Among authors: higashiyama y. Am J Nephrol. 2011;33(4):319-24. doi: 10.1159/000324885. Epub 2011 Mar 9. Am J Nephrol. 2011. PMID: 21389697
Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.
Bolati D, Shimizu H, Higashiyama Y, Nishijima F, Niwa T. Bolati D, et al. Among authors: higashiyama y. Am J Nephrol. 2011;34(4):318-23. doi: 10.1159/000330852. Epub 2011 Aug 18. Am J Nephrol. 2011. PMID: 21849772
Nuclear localization of magphinins, alternative splicing products of the human trophinin gene.
Aoyama J, Akazawa Y, Kasahara K, Higashiyama Y, Kikuchi I, Fukumoto Y, Saburi S, Nakayama Y, Fukuda MN, Yamaguchi N. Aoyama J, et al. Among authors: higashiyama y. J Cell Biochem. 2008 Feb 15;103(3):765-77. doi: 10.1002/jcb.21446. J Cell Biochem. 2008. PMID: 17559068
Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization.
Takahashi A, Obata Y, Fukumoto Y, Nakayama Y, Kasahara K, Kuga T, Higashiyama Y, Saito T, Yokoyama KK, Yamaguchi N. Takahashi A, et al. Among authors: higashiyama y. Exp Cell Res. 2009 Apr 15;315(7):1117-41. doi: 10.1016/j.yexcr.2009.02.010. Epub 2009 Feb 23. Exp Cell Res. 2009. PMID: 19245808
Induction of chromatin condensation by nuclear expression of a novel arginine-rich cationic protein genetically engineered from the enhanced green fluorescent protein.
Higashiyama Y, Takahashi A, Fukumoto Y, Nakayama Y, Yamaguchi N. Higashiyama Y, et al. Cytotechnology. 2009 Jul;60(1-3):153-9. doi: 10.1007/s10616-009-9227-7. Epub 2009 Sep 18. Cytotechnology. 2009. PMID: 19763862 Free PMC article.
Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface.
Kuga T, Hoshino M, Nakayama Y, Kasahara K, Ikeda K, Obata Y, Takahashi A, Higashiyama Y, Fukumoto Y, Yamaguchi N. Kuga T, et al. Among authors: higashiyama y. Exp Cell Res. 2008 Jun 10;314(10):2040-54. doi: 10.1016/j.yexcr.2008.03.018. Epub 2008 Apr 7. Exp Cell Res. 2008. PMID: 18457834
Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells.
Kuga T, Nakayama Y, Hoshino M, Higashiyama Y, Obata Y, Matsuda D, Kasahara K, Fukumoto Y, Yamaguchi N. Kuga T, et al. Among authors: higashiyama y. Arch Biochem Biophys. 2007 Oct 1;466(1):116-24. doi: 10.1016/j.abb.2007.07.002. Epub 2007 Jul 14. Arch Biochem Biophys. 2007. PMID: 17692281
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