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Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue.
Silenieks LB, Koch E, Higgins GA. Silenieks LB, et al. Among authors: higgins ga. Phytomedicine. 2013 Jan 15;20(2):172-7. doi: 10.1016/j.phymed.2012.10.004. Epub 2012 Nov 30. Phytomedicine. 2013. PMID: 23207249
Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats.
Guy EG, Fisher DC, Higgins GA, Fletcher PJ. Guy EG, et al. Among authors: higgins ga. Behav Pharmacol. 2014 Dec;25(8):775-83. doi: 10.1097/FBP.0000000000000092. Behav Pharmacol. 2014. PMID: 25230208
The anti-epileptic drug lacosamide (Vimpat) has anxiolytic property in rodents.
Higgins GA, Breysse N, Undzys E, Kuo C, Joharchi N, Derksen DR, Xin T, Isaac M, Slassi M. Higgins GA, et al. Eur J Pharmacol. 2009 Dec 10;624(1-3):1-9. doi: 10.1016/j.ejphar.2009.09.050. Epub 2009 Oct 7. Eur J Pharmacol. 2009. PMID: 19818346
Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property.
Higgins GA, Breysse N, Undzys E, Derksen DR, Jeffrey M, Scott BW, Xin T, Roucard C, Bressand K, Depaulis A, Burnham WM. Higgins GA, et al. Psychopharmacology (Berl). 2010 Jan;207(4):513-27. doi: 10.1007/s00213-009-1682-5. Epub 2009 Oct 16. Psychopharmacology (Berl). 2010. PMID: 19841906
Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement.
Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, LĂȘ AD, Higgins GA. Fletcher PJ, et al. Among authors: higgins ga. Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8. Neuropharmacology. 2012. PMID: 22342986
The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.
Higgins GA, Silenieks LB, Rossmann A, Rizos Z, Noble K, Soko AD, Fletcher PJ. Higgins GA, et al. Neuropsychopharmacology. 2012 Apr;37(5):1177-91. doi: 10.1038/npp.2011.303. Epub 2011 Dec 21. Neuropsychopharmacology. 2012. PMID: 22189292 Free PMC article.
The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues.
Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. Fletcher PJ, et al. Among authors: higgins ga. Neuropsychopharmacology. 2008 May;33(6):1402-12. doi: 10.1038/sj.npp.1301509. Epub 2007 Jul 25. Neuropsychopharmacology. 2008. PMID: 17653111
Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.
Fletcher PJ, Li Z, Silenieks LB, MacMillan C, DeLannoy I, Higgins GA. Fletcher PJ, et al. Among authors: higgins ga. Addict Biol. 2019 May;24(3):376-387. doi: 10.1111/adb.12602. Epub 2018 Mar 2. Addict Biol. 2019. PMID: 29498158
Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice.
Browne CJ, Ji X, Higgins GA, Fletcher PJ, Harvey-Lewis C. Browne CJ, et al. Among authors: higgins ga. Neuropsychopharmacology. 2017 Oct;42(11):2178-2187. doi: 10.1038/npp.2017.124. Epub 2017 Jun 13. Neuropsychopharmacology. 2017. PMID: 28720903 Free PMC article.
Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.
Fletcher PJ, Zeeb FD, Browne CJ, Higgins GA, Soko AD. Fletcher PJ, et al. Among authors: higgins ga. Psychopharmacology (Berl). 2017 Mar;234(5):889-902. doi: 10.1007/s00213-017-4529-5. Epub 2017 Jan 18. Psychopharmacology (Berl). 2017. PMID: 28097374
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