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Detecting recent positive selection in the human genome from haplotype structure.
Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Sabeti PC, et al. Among authors: higgins jm. Nature. 2002 Oct 24;419(6909):832-7. doi: 10.1038/nature01140. Epub 2002 Oct 9. Nature. 2002. PMID: 12397357
The structure of haplotype blocks in the human genome.
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. Gabriel SB, et al. Among authors: higgins j. Science. 2002 Jun 21;296(5576):2225-9. doi: 10.1126/science.1069424. Epub 2002 May 23. Science. 2002. PMID: 12029063
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D; International SNP Map Working Group. Sachidanandam R, et al. Among authors: higgins j. Nature. 2001 Feb 15;409(6822):928-33. doi: 10.1038/35057149. Nature. 2001. PMID: 11237013
Hematologic setpoints are a stable and patient-specific deep phenotype.
Foy BH, Petherbridge R, Roth M, Mow C, Patel HR, Patel CH, Ho SN, Lam E, Karczewski KJ, Tozzo V, Higgins JM. Foy BH, et al. Among authors: higgins jm. medRxiv [Preprint]. 2023 Sep 28:2023.09.26.23296146. doi: 10.1101/2023.09.26.23296146. medRxiv. 2023. PMID: 37808854 Free PMC article. Preprint.
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM. De Souza DC, et al. Among authors: higgins jm. Nat Commun. 2023 Sep 20;14(1):5850. doi: 10.1038/s41467-023-40923-5. Nat Commun. 2023. PMID: 37730674 Free PMC article.
Development of the Impact of Diagnosis Scale-Revised (IODS-R).
Arnold SRC, Huang Y, Lawson LP, Higgins JM, Hwang YIJ, Richdale A, Trollor JN. Arnold SRC, et al. Among authors: higgins jm. Assessment. 2023 Sep 12:10731911231196486. doi: 10.1177/10731911231196486. Online ahead of print. Assessment. 2023. PMID: 37700577 Free article.
161 results