Higgins L - Search Results

1

Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling.

Ge R, Rajeev V, Subramanian G, Reiss KA, Liu D, Higgins L, Joly A, Dugar S, Chakravarty J, Henson M, McEnroe G, Schreiner G, Reiss M. Ge R, et al. Among authors: higgins l. Biochem Pharmacol. 2004 Jul 1;68(1):41-50. doi: 10.1016/j.bcp.2004.03.011. Biochem Pharmacol. 2004. PMID: 15183116

2

Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M. Subramanian G, et al. Among authors: higgins l. Cancer Res. 2004 Aug 1;64(15):5200-11. doi: 10.1158/0008-5472.CAN-04-0018. Cancer Res. 2004. PMID: 15289325

3

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.

Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, Muiru GT, Murphy A, Higgins LS, Chakravarty S, Wong DH. Gaspar NJ, et al. Among authors: higgins ls. Mol Pharmacol. 2007 Jul;72(1):152-61. doi: 10.1124/mol.106.029025. Epub 2007 Mar 30. Mol Pharmacol. 2007. PMID: 17400764

4

Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

Kapoun AM, Gaspar NJ, Wang Y, Damm D, Liu YW, O'young G, Quon D, Lam A, Munson K, Tran TT, Ma JY, Murphy A, Dugar S, Chakravarty S, Protter AA, Wen FQ, Liu X, Rennard SI, Higgins LS. Kapoun AM, et al. Mol Pharmacol. 2006 Aug;70(2):518-31. doi: 10.1124/mol.105.021600. Epub 2006 May 17. Mol Pharmacol. 2006. PMID: 16707625

5

Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.

Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. Bonniaud P, et al. Among authors: higgins l. Am J Respir Crit Care Med. 2005 Apr 15;171(8):889-98. doi: 10.1164/rccm.200405-612OC. Epub 2004 Nov 24. Am J Respir Crit Care Med. 2005. PMID: 15563636

6

Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model.

Tran TT, Uhl M, Ma JY, Janssen L, Sriram V, Aulwurm S, Kerr I, Lam A, Webb HK, Kapoun AM, Kizer DE, McEnroe G, Hart B, Axon J, Murphy A, Chakravarty S, Dugar S, Protter AA, Higgins LS, Wick W, Weller M, Wong DH. Tran TT, et al. Among authors: higgins ls. Neuro Oncol. 2007 Jul;9(3):259-70. doi: 10.1215/15228517-2007-010. Epub 2007 May 23. Neuro Oncol. 2007. PMID: 17522330 Free PMC article.

7

Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase.

Koppelman B, Webb HK, Medicherla S, Almirez R, Feng Y, Chavez JC, Mao CP, Nguyen A, Liu YW, Kapoun AM, Muiru G, Huang YA, Dugar S, Mavunkel BJ, Lim DW, Chakravarty S, Luedtke G, Protter AA, Higgins LS. Koppelman B, et al. Pharmacology. 2008;81(3):204-20. doi: 10.1159/000112865. Epub 2008 Jan 7. Pharmacology. 2008. PMID: 18176091

8

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.

Medicherla S, Fitzgerald MF, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, Higgins LS. Medicherla S, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):921-9. doi: 10.1124/jpet.107.127092. Epub 2007 Dec 4. J Pharmacol Exp Ther. 2008. PMID: 18056868

9

Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.

Medicherla S, Li L, Ma JY, Kapoun AM, Gaspar NJ, Liu YW, Mangadu R, O'Young G, Protter AA, Schreiner GF, Wong DH, Higgins LS. Medicherla S, et al. Among authors: higgins ls. Anticancer Res. 2007 Nov-Dec;27(6B):4149-57. Anticancer Res. 2007. PMID: 18229422 Free article.

10

p38 Inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells.

Lim MY, Wang H, Kapoun AM, O'connell M, O'Young G, Brauer HA, Luedtke GR, Chakravarty S, Dugar S, Schreiner GS, Protter AA, Higgins LS. Lim MY, et al. J Mol Cell Cardiol. 2004 Dec;37(6):1111-4. doi: 10.1016/j.yjmcc.2004.09.015. J Mol Cell Cardiol. 2004. PMID: 15572041

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