Higgins LG - Search Results

1

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.

MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, Hayes JD. MacLeod AK, et al. Among authors: higgins lg. Carcinogenesis. 2009 Sep;30(9):1571-80. doi: 10.1093/carcin/bgp176. Epub 2009 Jul 16. Carcinogenesis. 2009. PMID: 19608619 Free PMC article.

2

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, Hayes JD. Higgins LG, et al. Toxicol Appl Pharmacol. 2009 Jun 15;237(3):267-80. doi: 10.1016/j.taap.2009.03.005. Epub 2009 Mar 20. Toxicol Appl Pharmacol. 2009. PMID: 19303893

3

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT. Wang XJ, et al. Among authors: higgins lg. Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013. Chem Biol. 2010. PMID: 20142043

4

The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

Higgins LG, Hayes JD. Higgins LG, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):37-45. doi: 10.1016/j.cbi.2010.09.025. Epub 2010 Oct 23. Chem Biol Interact. 2011. PMID: 20932822

5

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD. McWalter GK, et al. Among authors: higgins lg. J Nutr. 2004 Dec;134(12 Suppl):3499S-3506S. doi: 10.1093/jn/134.12.3499S. J Nutr. 2004. PMID: 15570060 Free article.

6

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.

Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD. Higgins LG, et al. Toxicol Appl Pharmacol. 2008 Feb 1;226(3):328-37. doi: 10.1016/j.taap.2007.09.018. Epub 2007 Sep 26. Toxicol Appl Pharmacol. 2008. PMID: 18028974

7

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.

Higgins LG, Hayes JD. Higgins LG, et al. Drug Metab Rev. 2011 May;43(2):92-137. doi: 10.3109/03602532.2011.567391. Drug Metab Rev. 2011. PMID: 21495793 Review.

8

Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.

MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD. MacLeod AK, et al. Among authors: higgins lg. Drug Metab Dispos. 2010 Feb;38(2):341-6. doi: 10.1124/dmd.109.030544. Epub 2009 Nov 17. Drug Metab Dispos. 2010. PMID: 19920056

9

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

Soriano FX, Léveillé F, Papadia S, Higgins LG, Varley J, Baxter P, Hayes JD, Hardingham GE. Soriano FX, et al. Among authors: higgins lg. J Neurochem. 2008 Oct;107(2):533-43. doi: 10.1111/j.1471-4159.2008.05648.x. Epub 2008 Sep 16. J Neurochem. 2008. PMID: 18761713 Free PMC article.

10

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK. Kitteringham NR, et al. J Proteomics. 2010 Jun 16;73(8):1612-31. doi: 10.1016/j.jprot.2010.03.018. Epub 2010 Apr 24. J Proteomics. 2010. PMID: 20399915 Free PMC article.

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