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Domain swapping in G-protein coupled receptor dimers.
Gouldson PR, Snell CR, Bywater RP, Higgs C, Reynolds CA. Gouldson PR, et al. Among authors: higgs c. Protein Eng. 1998 Dec;11(12):1181-93. doi: 10.1093/protein/11.12.1181. Protein Eng. 1998. PMID: 9930667
Dimerization of G-protein-coupled receptors.
Dean MK, Higgs C, Smith RE, Bywater RP, Snell CR, Scott PD, Upton GJ, Howe TJ, Reynolds CA. Dean MK, et al. Among authors: higgs c. J Med Chem. 2001 Dec 20;44(26):4595-614. doi: 10.1021/jm010290+. J Med Chem. 2001. PMID: 11741478
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Cramp S, Dyke HJ, Higgs C, Clark DE, Gill M, Savy P, Jennings N, Price S, Lockey PM, Norman D, Porres S, Wilson F, Jones A, Ramsden N, Mangano R, Leggate D, Andersson M, Hale R. Cramp S, et al. Among authors: higgs c. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. doi: 10.1016/j.bmcl.2010.02.097. Epub 2010 Mar 3. Bioorg Med Chem Lett. 2010. PMID: 20299215
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.
Ramachandran SA, Jadhavar PS, Miglani SK, Singh MP, Kalane DP, Agarwal AK, Sathe BD, Mukherjee K, Gupta A, Haldar S, Raja M, Singh S, Pham SM, Chakravarty S, Quinn K, Belmar S, Alfaro IE, Higgs C, Bernales S, Herrera FJ, Rai R. Ramachandran SA, et al. Among authors: higgs c. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. doi: 10.1016/j.bmcl.2017.03.064. Epub 2017 Mar 24. Bioorg Med Chem Lett. 2017. PMID: 28377059
Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL, MacKenzie RE, Duttaroy A, Gangl E, Maniara W, Sedrani R, Namoto K, Ostermann N, Gerhartz B, Sirockin F, Trappe J, Hassiepen U, Baeschlin DK. Sutton JM, et al. Among authors: higgs c. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1464-8. doi: 10.1016/j.bmcl.2011.11.054. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22177783
154 results