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Formin proteins: a domain-based approach.
Higgs HN. Higgs HN. Trends Biochem Sci. 2005 Jun;30(6):342-53. doi: 10.1016/j.tibs.2005.04.014. Trends Biochem Sci. 2005. PMID: 15950879 Review.
The harder the better: effects of substrate rigidity on cell motility.
Higgs HN. Higgs HN. Trends Biochem Sci. 2000 Sep;25(9):427. doi: 10.1016/s0968-0004(00)01653-4. Trends Biochem Sci. 2000. PMID: 10986457 No abstract available.
Branching out: cortactin stabilizes actin networks generated by the Arp2/3 complex.
Higgs H. Higgs H. Trends Biochem Sci. 2001 Apr;26(4):219. doi: 10.1016/s0968-0004(01)01829-1. Trends Biochem Sci. 2001. PMID: 11295544 No abstract available.
Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.
Higgs HN, Pollard TD. Higgs HN, et al. Annu Rev Biochem. 2001;70:649-76. doi: 10.1146/annurev.biochem.70.1.649. Annu Rev Biochem. 2001. PMID: 11395419 Review.
Actin nucleation: nucleation-promoting factors are not all equal.
Higgs HN. Higgs HN. Curr Biol. 2001 Dec 11;11(24):R1009-12. doi: 10.1016/s0960-9822(01)00612-1. Curr Biol. 2001. PMID: 11747836 Review.
Actin nucleation: cortactin caught in the act.
Higgs HN. Higgs HN. Curr Biol. 2002 Sep 3;12(17):R593-5. doi: 10.1016/s0960-9822(02)01101-6. Curr Biol. 2002. PMID: 12225681
The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition.
Li F, Higgs HN. Li F, et al. Among authors: higgs hn. Curr Biol. 2003 Aug 5;13(15):1335-40. doi: 10.1016/s0960-9822(03)00540-2. Curr Biol. 2003. PMID: 12906795
The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments.
Harris ES, Li F, Higgs HN. Harris ES, et al. Among authors: higgs hn. J Biol Chem. 2004 May 7;279(19):20076-87. doi: 10.1074/jbc.M312718200. Epub 2004 Feb 29. J Biol Chem. 2004. PMID: 14990563
Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology.
Majstoravich S, Zhang J, Nicholson-Dykstra S, Linder S, Friedrich W, Siminovitch KA, Higgs HN. Majstoravich S, et al. Among authors: higgs hn. Blood. 2004 Sep 1;104(5):1396-403. doi: 10.1182/blood-2004-02-0437. Epub 2004 May 6. Blood. 2004. PMID: 15130947
Actin cytoskeleton: formins lead the way.
Harris ES, Higgs HN. Harris ES, et al. Among authors: higgs hn. Curr Biol. 2004 Jul 13;14(13):R520-2. doi: 10.1016/j.cub.2004.06.043. Curr Biol. 2004. PMID: 15242634 Review.
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