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Hsc70-binding peptides selected from a phage display peptide library that resemble organellar targeting sequences.
Takenaka IM, Leung SM, McAndrew SJ, Brown JP, Hightower LE. Takenaka IM, et al. Among authors: hightower le. J Biol Chem. 1995 Aug 25;270(34):19839-44. doi: 10.1074/jbc.270.34.19839. J Biol Chem. 1995. PMID: 7649995
The promise of molecular biomarkers for environmental monitoring.
Hightower LE. Hightower LE. Biol Chem. 1998 Oct;379(10):1213-5. Biol Chem. 1998. PMID: 9820581 No abstract available.
A 16-kDa protein functions as a new regulatory protein for Hsc70 molecular chaperone and is identified as a member of the Nm23/nucleoside diphosphate kinase family.
Leung SM, Hightower LE. Leung SM, et al. Among authors: hightower le. J Biol Chem. 1997 Jan 31;272(5):2607-14. doi: 10.1074/jbc.272.5.2607. J Biol Chem. 1997. PMID: 9006893
A mutational study of the peptide-binding domain of Hsc70 guided by secondary structure prediction.
Boice JA, Hightower LE. Boice JA, et al. Among authors: hightower le. J Biol Chem. 1997 Oct 3;272(40):24825-31. doi: 10.1074/jbc.272.40.24825. J Biol Chem. 1997. PMID: 9312080
Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer.
Leung SM, Senisterra G, Ritchie KP, Sadis SE, Lepock JR, Hightower LE. Leung SM, et al. Among authors: hightower le. Cell Stress Chaperones. 1996 Apr;1(1):78-89. doi: 10.1379/1466-1268(1996)001<0078:taotbh>2.3.co;2. Cell Stress Chaperones. 1996. PMID: 9222592 Free PMC article.
Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange.
Sadis S, Hightower LE. Sadis S, et al. Among authors: hightower le. Biochemistry. 1992 Oct 6;31(39):9406-12. doi: 10.1021/bi00154a012. Biochemistry. 1992. PMID: 1356434
Effects of dexamethasone, heat shock, and serum responses on the inhibition of Hsc70 synthesis by antisense RNA in NIH 3T3 cells.
Li T, Hightower LE. Li T, et al. Among authors: hightower le. J Cell Physiol. 1995 Aug;164(2):344-55. doi: 10.1002/jcp.1041640215. J Cell Physiol. 1995. PMID: 7542664
Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection.
Noonan E, Giardina C, Hightower L. Noonan E, et al. Exp Cell Res. 2008 Aug 1;314(13):2468-76. doi: 10.1016/j.yexcr.2008.05.002. Epub 2008 May 17. Exp Cell Res. 2008. PMID: 18579131
Cell surface expression of heat shock proteins and the immune response.
Multhoff G, Hightower LE. Multhoff G, et al. Among authors: hightower le. Cell Stress Chaperones. 1996 Sep;1(3):167-76. doi: 10.1379/1466-1268(1996)001<0167:cseohs>2.3.co;2. Cell Stress Chaperones. 1996. PMID: 9222602 Free PMC article. Review.
Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response.
House SD, Guidon PT Jr, Perdrizet GA, Rewinski M, Kyriakos R, Bockman RS, Mistry T, Gallagher RA, Hightower LE. House SD, et al. Among authors: hightower le. Cell Stress Chaperones. 2001 Apr;6(2):164-71. doi: 10.1379/1466-1268(2001)006<0164:eohssc>2.0.co;2. Cell Stress Chaperones. 2001. PMID: 11599578 Free PMC article.
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