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1,745 results
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Scaffolding function of PAK in the PDK1-Akt pathway.
Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Higuchi M, et al. Nat Cell Biol. 2008 Nov;10(11):1356-64. doi: 10.1038/ncb1795. Epub 2008 Oct 19. Nat Cell Biol. 2008. PMID: 18931661
PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, Miyata T, Nakajima K, Gotoh Y. Itoh Y, et al. Among authors: higuchi m. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2955-64. doi: 10.1073/pnas.1516321113. Epub 2016 May 11. Proc Natl Acad Sci U S A. 2016. PMID: 27170189 Free PMC article.
Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation.
Okazaki T, Higuchi M, Gotoh Y. Okazaki T, et al. Among authors: higuchi m. Genes Cells. 2013 Jun;18(6):493-501. doi: 10.1111/gtc.12052. Epub 2013 Apr 11. Genes Cells. 2013. PMID: 23574001
Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells.
Higuchi M, Kihara R, Okazaki T, Aoki I, Suetsugu S, Gotoh Y. Higuchi M, et al. J Cell Sci. 2013 Feb 1;126(Pt 3):745-55. doi: 10.1242/jcs.112722. Epub 2012 Dec 21. J Cell Sci. 2013. PMID: 23264741
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.
Mori Y, Higuchi M, Hirabayashi Y, Fukuda M, Gotoh Y. Mori Y, et al. Among authors: higuchi m. EMBO J. 2008 Jan 9;27(1):76-87. doi: 10.1038/sj.emboj.7601935. Epub 2007 Nov 29. EMBO J. 2008. PMID: 18046461 Free PMC article.
The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts.
Onishi K, Higuchi M, Asakura T, Masuyama N, Gotoh Y. Onishi K, et al. Among authors: higuchi m. Genes Cells. 2007 Apr;12(4):535-46. doi: 10.1111/j.1365-2443.2007.01071.x. Genes Cells. 2007. PMID: 17397400
Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells.
Mori Y, Higuchi M, Masuyama N, Gotoh Y. Mori Y, et al. Among authors: higuchi m. Cell Struct Funct. 2004 Dec;29(4):101-10. doi: 10.1247/csf.29.101. Cell Struct Funct. 2004. PMID: 15665505
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling.
Shinohara M, Terada Y, Iwamatsu A, Shinohara A, Mochizuki N, Higuchi M, Gotoh Y, Ihara S, Nagata S, Itoh H, Fukui Y, Jessberger R. Shinohara M, et al. Among authors: higuchi m. Nature. 2002 Apr 18;416(6882):759-63. doi: 10.1038/416759a. Nature. 2002. PMID: 11961559
The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells.
Higuchi M, Onishi K, Masuyama N, Gotoh Y. Higuchi M, et al. Genes Cells. 2003 Aug;8(8):657-69. doi: 10.1046/j.1365-2443.2003.00663.x. Genes Cells. 2003. PMID: 12875651
Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.
Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H. Takayama K, et al. Among authors: higuchi m. Mol Ther. 2012 Jan;20(1):127-37. doi: 10.1038/mt.2011.234. Epub 2011 Nov 8. Mol Ther. 2012. PMID: 22068426 Free PMC article.
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