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1,246 results
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Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.
Ieiri I, Higuchi S, Sugiyama Y. Ieiri I, et al. Among authors: higuchi s. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):703-29. doi: 10.1517/17425250902976854. Expert Opin Drug Metab Toxicol. 2009. PMID: 19442037 Review.
Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.
Sasaki T, Hirota T, Ryokai Y, Kobayashi D, Kimura M, Irie S, Higuchi S, Ieiri I. Sasaki T, et al. Among authors: higuchi s. Drug Metab Pharmacokinet. 2011;26(4):374-86. doi: 10.2133/dmpk.dmpk-10-rg-103. Epub 2011 Apr 22. Drug Metab Pharmacokinet. 2011. PMID: 21512263
Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome.
Kanda D, Takagi H, Kawahara Y, Yata Y, Takakusagi T, Hatanaka T, Yoshinaga T, Iesaki K, Kashiwabara K, Higuchi T, Mori M, Hirota T, Higuchi S, Ieiri I. Kanda D, et al. Among authors: higuchi t, higuchi s. Drug Metab Pharmacokinet. 2009;24(5):464-8. doi: 10.2133/dmpk.24.464. Drug Metab Pharmacokinet. 2009. PMID: 19881259
Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms.
Hirota T, Takane H, Higuchi S, Ieiri I. Hirota T, et al. Among authors: higuchi s. Curr Drug Metab. 2008 Jan;9(1):34-8. doi: 10.2174/138920008783331130. Curr Drug Metab. 2008. PMID: 18220569 Review.
Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.
Tanigawa T, Heinig R, Kuroki Y, Higuchi S. Tanigawa T, et al. Among authors: higuchi s. Drug Metab Pharmacokinet. 2006 Feb;21(1):61-9. doi: 10.2133/dmpk.21.61. Drug Metab Pharmacokinet. 2006. PMID: 16547395 Clinical Trial.
Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).
Honda T, Dan Y, Koyabu N, Ieiri I, Otsubo K, Higuchi S, Ohtani H, Sawada Y. Honda T, et al. Among authors: higuchi s. Drug Metab Pharmacokinet. 2002;17(5):479-81. doi: 10.2133/dmpk.17.479. Drug Metab Pharmacokinet. 2002. PMID: 15618700
[Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].
Ieiri I, Higuchi S. Ieiri I, et al. Among authors: higuchi s. Yakugaku Zasshi. 2009 Feb;129(2):231-5. doi: 10.1248/yakushi.129.231. Yakugaku Zasshi. 2009. PMID: 19182452 Review. Japanese.
Polymorphism in human organic cation transporters and metformin action.
Takane H, Shikata E, Otsubo K, Higuchi S, Ieiri I. Takane H, et al. Among authors: higuchi s. Pharmacogenomics. 2008 Apr;9(4):415-22. doi: 10.2217/14622416.9.4.415. Pharmacogenomics. 2008. PMID: 18384255 Review.
Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients.
Sasaki T, Takane H, Ogawa K, Isagawa S, Hirota T, Higuchi S, Horii T, Otsubo K, Ieiri I. Sasaki T, et al. Among authors: higuchi s. Antimicrob Agents Chemother. 2011 May;55(5):1867-73. doi: 10.1128/AAC.01185-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357301 Free PMC article. Clinical Trial.
Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells.
Dohgu S, Yamauchi A, Takata F, Naito M, Tsuruo T, Higuchi S, Sawada Y, Kataoka Y. Dohgu S, et al. Among authors: higuchi s. Cell Mol Neurobiol. 2004 Jun;24(3):491-7. doi: 10.1023/b:cemn.0000022776.47302.ce. Cell Mol Neurobiol. 2004. PMID: 15206827
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