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Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.
Ahlin G, Hilgendorf C, Karlsson J, Szigyarto CA, Uhlén M, Artursson P. Ahlin G, et al. Among authors: hilgendorf c. Drug Metab Dispos. 2009 Dec;37(12):2275-83. doi: 10.1124/dmd.109.028654. Epub 2009 Sep 9. Drug Metab Dispos. 2009. PMID: 19741037
Finally, the function of one ubiquitously expressed transporter, MCT1/SLC16A1, was investigated using [(14)C]lactic acid as a substrate. ...
Finally, the function of one ubiquitously expressed transporter, MCT1/SLC16A1, was investigated using [(14)C]lactic acid as a substra …
Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and preclinical development.
Karlsson FH, Bouchene S, Hilgendorf C, Dolgos H, Peters SA. Karlsson FH, et al. Among authors: hilgendorf c. Drug Metab Dispos. 2013 Dec;41(12):2033-46. doi: 10.1124/dmd.113.051664. Epub 2013 Aug 5. Drug Metab Dispos. 2013. PMID: 23918667
Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.
Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J. Hilgendorf C, et al. Drug Metab Dispos. 2007 Aug;35(8):1333-40. doi: 10.1124/dmd.107.014902. Epub 2007 May 11. Drug Metab Dispos. 2007. PMID: 17496207
Transporters that were highly expressed in the intestine included HPT1, PEPT1, BCRP, MRP2, and MDR1, whereas, in the liver, OCT1, MRP2, OATP-C, NTCP and BSEP were the main transporters. ...
Transporters that were highly expressed in the intestine included HPT1, PEPT1, BCRP, MRP2, and MDR1, whereas, in the liver, OCT1, MRP2, OATP …
Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.
Hutter V, Chau DY, Hilgendorf C, Brown A, Cooper A, Zann V, Pritchard DI, Bosquillon C. Hutter V, et al. Among authors: hilgendorf c. Eur J Pharm Biopharm. 2014 Jan;86(1):74-82. doi: 10.1016/j.ejpb.2013.06.010. Epub 2013 Jun 28. Eur J Pharm Biopharm. 2014. PMID: 23816640
Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.
Hilgendorf C, Spahn-Langguth H, Rhedin M, Regårdh CG, Löwenadler B, Langguth P. Hilgendorf C, et al. Mol Pharm. 2005 Jan-Feb;2(1):64-73. doi: 10.1021/mp049931y. Mol Pharm. 2005. PMID: 15804179
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.
Seithel A, Karlsson J, Hilgendorf C, Björquist A, Ungell AL. Seithel A, et al. Among authors: hilgendorf c. Eur J Pharm Sci. 2006 Jul;28(4):291-9. doi: 10.1016/j.ejps.2006.03.003. Epub 2006 Mar 22. Eur J Pharm Sci. 2006. PMID: 16704924
Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.
Soltanpour Y, Hilgendorf C, Ahlström MM, Foster AJ, Kenna JG, Petersen A, Ungell AL. Soltanpour Y, et al. Among authors: hilgendorf c. Drug Metab Dispos. 2012 Nov;40(11):2054-8. doi: 10.1124/dmd.112.045815. Epub 2012 Jul 30. Drug Metab Dispos. 2012. PMID: 22851615
Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function.
Miliotis T, Ali L, Palm JE, Lundqvist AJ, Ahnoff M, Andersson TB, Hilgendorf C. Miliotis T, et al. Among authors: hilgendorf c. Drug Metab Dispos. 2011 Dec;39(12):2440-9. doi: 10.1124/dmd.111.040774. Epub 2011 Sep 23. Drug Metab Dispos. 2011. PMID: 21949244
High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells.
Karlsson JE, Heddle C, Rozkov A, Rotticci-Mulder J, Tuvesson O, Hilgendorf C, Andersson TB. Karlsson JE, et al. Among authors: hilgendorf c. Drug Metab Dispos. 2010 Apr;38(4):705-14. doi: 10.1124/dmd.109.028886. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071452
Modeling of drug-transporter interactions using structural information.
Winiwarter S, Hilgendorf C. Winiwarter S, et al. Among authors: hilgendorf c. Curr Opin Drug Discov Devel. 2008 Jan;11(1):95-103. Curr Opin Drug Discov Devel. 2008. PMID: 18175272 Review.
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