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From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design.
Hilgenfeld R. Hilgenfeld R. FEBS J. 2014 Sep;281(18):4085-96. doi: 10.1111/febs.12936. Epub 2014 Aug 11. FEBS J. 2014. PMID: 25039866 Free PMC article. Review.
Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease.
Hammamy MZ, Haase C, Hammami M, Hilgenfeld R, Steinmetzer T. Hammamy MZ, et al. Among authors: hilgenfeld r. ChemMedChem. 2013 Feb;8(2):231-41. doi: 10.1002/cmdc.201200497. Epub 2013 Jan 10. ChemMedChem. 2013. PMID: 23307694
Computer-Aided Structure Based Drug Design Approaches for the Discovery of New Anti-CHIKV Agents.
Jadav SS, Sinha BN, Hilgenfeld R, Jayaprakash V. Jadav SS, et al. Among authors: hilgenfeld r. Curr Comput Aided Drug Des. 2017 Nov 10;13(4):346-361. doi: 10.2174/1573409913666170309145308. Curr Comput Aided Drug Des. 2017. PMID: 28294048 Review.
Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.
Nitsche C, Zhang L, Weigel LF, Schilz J, Graf D, Bartenschlager R, Hilgenfeld R, Klein CD. Nitsche C, et al. Among authors: hilgenfeld r. J Med Chem. 2017 Jan 12;60(1):511-516. doi: 10.1021/acs.jmedchem.6b01021. Epub 2016 Dec 14. J Med Chem. 2017. PMID: 27966962
Thiazolidone derivatives as inhibitors of chikungunya virus.
Jadav SS, Sinha BN, Hilgenfeld R, Pastorino B, de Lamballerie X, Jayaprakash V. Jadav SS, et al. Among authors: hilgenfeld r. Eur J Med Chem. 2015 Jan 7;89:172-8. doi: 10.1016/j.ejmech.2014.10.042. Epub 2014 Oct 16. Eur J Med Chem. 2015. PMID: 25462237
Recent advances in targeting viral proteases for the discovery of novel antivirals.
Steuber H, Hilgenfeld R. Steuber H, et al. Among authors: hilgenfeld r. Curr Top Med Chem. 2010;10(3):323-45. doi: 10.2174/156802610790725470. Curr Top Med Chem. 2010. PMID: 20166951 Review.
Viral Entry and NS1 as Potential Antiviral Drug Targets.
de Silva AM, Rey FA, Young PR, Hilgenfeld R, Vasudevan SG. de Silva AM, et al. Among authors: hilgenfeld r. Adv Exp Med Biol. 2018;1062:107-113. doi: 10.1007/978-981-10-8727-1_8. Adv Exp Med Biol. 2018. PMID: 29845528 Review.
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
Lei J, Kusov Y, Hilgenfeld R. Lei J, et al. Among authors: hilgenfeld r. Antiviral Res. 2018 Jan;149:58-74. doi: 10.1016/j.antiviral.2017.11.001. Epub 2017 Nov 8. Antiviral Res. 2018. PMID: 29128390 Free PMC article. Review.
Antiviral strategies to control calicivirus infections.
Rohayem J, Bergmann M, Gebhardt J, Gould E, Tucker P, Mattevi A, Unge T, Hilgenfeld R, Neyts J. Rohayem J, et al. Among authors: hilgenfeld r. Antiviral Res. 2010 Aug;87(2):162-78. doi: 10.1016/j.antiviral.2010.05.002. Epub 2010 May 21. Antiviral Res. 2010. PMID: 20471996 Free PMC article. Review.
Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus.
Wang H, Han M, Qi J, Hilgenfeld R, Luo T, Shi Y, Gao GF, Song H. Wang H, et al. Among authors: hilgenfeld r. Sci China Life Sci. 2017 Dec;60(12):1403-1406. doi: 10.1007/s11427-017-9238-8. Epub 2017 Nov 29. Sci China Life Sci. 2017. PMID: 29285718 No abstract available.
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