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Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.
Kastaniotis AJ, Autio KJ, Sormunen RT, Hiltunen JK. Kastaniotis AJ, et al. Among authors: hiltunen jk. Mol Microbiol. 2004 Sep;53(5):1407-21. doi: 10.1111/j.1365-2958.2004.04191.x. Mol Microbiol. 2004. PMID: 15387819
The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA.
Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK. Kasaragod P, et al. Among authors: hiltunen jk. FEBS J. 2013 Jul;280(13):3160-75. doi: 10.1111/febs.12150. Epub 2013 Feb 15. FEBS J. 2013. PMID: 23351063
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes.
Hiltunen JK, Kastaniotis AJ, Autio KJ, Jiang G, Chen Z, Glumoff T. Hiltunen JK, et al. Mol Cell Endocrinol. 2019 Jun 1;489:107-118. doi: 10.1016/j.mce.2018.11.012. Epub 2018 Nov 30. Mol Cell Endocrinol. 2019. PMID: 30508570 Review.
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z. Venkatesan R, et al. Among authors: hiltunen jk. Nat Commun. 2014 Sep 9;5:4805. doi: 10.1038/ncomms5805. Nat Commun. 2014. PMID: 25203508
Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.
Nair RR, Kerätär JM, Autio KJ, Masud AJ, Finnilä MAJ, Autio-Harmainen HI, Miinalainen IJ, Nieminen PA, Hiltunen JK, Kastaniotis AJ. Nair RR, et al. Among authors: hiltunen jk. Hum Mol Genet. 2017 Jun 1;26(11):2104-2117. doi: 10.1093/hmg/ddx105. Hum Mol Genet. 2017. PMID: 28369354
Mitochondrial fatty acid synthesis type II: more than just fatty acids.
Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL. Hiltunen JK, et al. J Biol Chem. 2009 Apr 3;284(14):9011-5. doi: 10.1074/jbc.R800068200. Epub 2008 Nov 21. J Biol Chem. 2009. PMID: 19028688 Free PMC article. Review.
Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria.
Schonauer MS, Kastaniotis AJ, Hiltunen JK, Dieckmann CL. Schonauer MS, et al. Among authors: hiltunen jk. Mol Cell Biol. 2008 Nov;28(21):6646-57. doi: 10.1128/MCB.01162-08. Epub 2008 Sep 8. Mol Cell Biol. 2008. PMID: 18779316 Free PMC article.
An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.
Autio KJ, Kastaniotis AJ, Pospiech H, Miinalainen IJ, Schonauer MS, Dieckmann CL, Hiltunen JK. Autio KJ, et al. Among authors: hiltunen jk. FASEB J. 2008 Feb;22(2):569-78. doi: 10.1096/fj.07-8986. Epub 2007 Sep 26. FASEB J. 2008. PMID: 17898086
MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder.
Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F; University of Washington Center for Mendelian Genomics, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ. Heimer G, et al. Among authors: hiltunen jk. Am J Hum Genet. 2016 Dec 1;99(6):1229-1244. doi: 10.1016/j.ajhg.2016.09.021. Epub 2016 Nov 3. Am J Hum Genet. 2016. PMID: 27817865 Free PMC article.
On the molecular basis of D-bifunctional protein deficiency type III.
Mehtälä ML, Lensink MF, Pietikäinen LP, Hiltunen JK, Glumoff T. Mehtälä ML, et al. Among authors: hiltunen jk. PLoS One. 2013;8(1):e53688. doi: 10.1371/journal.pone.0053688. Epub 2013 Jan 7. PLoS One. 2013. PMID: 23308274 Free PMC article.
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