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Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance.
Eletsky A, Kienhöfer A, Hilvert D, Pervushin K. Eletsky A, et al. Biochemistry. 2005 May 10;44(18):6788-99. doi: 10.1021/bi0474259. Biochemistry. 2005. PMID: 15865424
Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.
Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D. Müller MM, et al. PLoS Genet. 2013;9(1):e1003187. doi: 10.1371/journal.pgen.1003187. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300488 Free PMC article.
Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam.
Vandemeulebroucke A, Aldag C, Stiebritz MT, Reiher M, Hilvert D. Vandemeulebroucke A, et al. Biochemistry. 2015 Nov 10;54(44):6692-703. doi: 10.1021/acs.biochem.5b00939. Epub 2015 Oct 27. Biochemistry. 2015. PMID: 26460790
Design, selection, and characterization of a split chorismate mutase.
Müller MM, Kries H, Csuhai E, Kast P, Hilvert D. Müller MM, et al. Protein Sci. 2010 May;19(5):1000-10. doi: 10.1002/pro.377. Protein Sci. 2010. PMID: 20306491 Free PMC article.
A simple selection strategy for evolving highly efficient enzymes.
Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D. Neuenschwander M, et al. Nat Biotechnol. 2007 Oct;25(10):1145-7. doi: 10.1038/nbt1341. Epub 2007 Sep 16. Nat Biotechnol. 2007. PMID: 17873865
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