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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J. Hinchliffe P, et al. Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392. Sci Rep. 2017. PMID: 28059088 Free PMC article.
Structure and operation of bacterial tripartite pumps.
Hinchliffe P, Symmons MF, Hughes C, Koronakis V. Hinchliffe P, et al. Annu Rev Microbiol. 2013;67:221-42. doi: 10.1146/annurev-micro-092412-155718. Epub 2013 Jun 26. Annu Rev Microbiol. 2013. PMID: 23808339 Review.
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms.
Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T. Yang Q, et al. Among authors: hinchliffe p. Nat Commun. 2017 Dec 12;8(1):2054. doi: 10.1038/s41467-017-02149-0. Nat Commun. 2017. PMID: 29233990 Free PMC article.
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