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Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.
Angata K, Suzuki M, McAuliffe J, Ding Y, Hindsgaul O, Fukuda M. Angata K, et al. Among authors: Hindsgaul O. J Biol Chem. 2000 Jun 16;275(24):18594-601. doi: 10.1074/jbc.M910204199. J Biol Chem. 2000. PMID: 10766765
Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.
Yeh JC, Hiraoka N, Petryniak B, Nakayama J, Ellies LG, Rabuka D, Hindsgaul O, Marth JD, Lowe JB, Fukuda M. Yeh JC, et al. Among authors: Hindsgaul O. Cell. 2001 Jun 29;105(7):957-69. doi: 10.1016/s0092-8674(01)00394-4. Cell. 2001. PMID: 11439191
We now identify a sulfated extended core1 mucin-type O-glycan, Gal beta 1-->4(sulfo-->6)GlcNAc beta 1-->3Gal beta 1-->3GalNAc, as the MECA-79 epitope. ...These results identify Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing....
We now identify a sulfated extended core1 mucin-type O-glycan, Gal beta 1-->4(sulfo-->6)GlcNAc beta 1-->3Gal beta 1-->3Ga …
Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.
Ong E, Suzuki M, Belot F, Yeh JC, Franceschini I, Angata K, Hindsgaul O, Fukuda M. Ong E, et al. Among authors: Hindsgaul O. J Biol Chem. 2002 May 17;277(20):18182-90. doi: 10.1074/jbc.M201312200. Epub 2002 Mar 12. J Biol Chem. 2002. PMID: 11891229
In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST. ...These results combined together indicate that HNK-1 glycan can be synthesized on core 2 branched O-glycans but that the HNK-1 glycan is preferentially added on N-glycans over O-glycans of NCAM, probably because N-glycans are extended further than O-glycans attached to NCAM containing the muscle-specific domain....
In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-g …
Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.
Akama TO, Misra AK, Hindsgaul O, Fukuda MN. Akama TO, et al. Among authors: Hindsgaul O. J Biol Chem. 2002 Nov 8;277(45):42505-13. doi: 10.1074/jbc.M207412200. Epub 2002 Sep 5. J Biol Chem. 2002. PMID: 12218059
Among the enzymes of the carbohydrate sulfotransferase family, human corneal GlcNAc 6-O-sulfotransferase (hCGn6ST, also known as human GlcNAc6ST-5/GST4beta) and human intestinal GlcNAc 6-O-sulfotransferase (hIGn6ST or human GlcNAc6ST-3/GST4alpha) are highly homologous. ...O., Nakayama, J., Nishida, K., Hiraoka, N., Suzuki, M., McAuliffe, J., Hindsgaul, O., Fukuda, M., and Fukuda, M. N. (2001) J. ...
Among the enzymes of the carbohydrate sulfotransferase family, human corneal GlcNAc 6-O-sulfotransferase (hCGn6ST, also known as huma …
CMP substitutions preferentially inhibit polysialic acid synthesis.
Miyazaki T, Angata K, Seeberger PH, Hindsgaul O, Fukuda M. Miyazaki T, et al. Among authors: Hindsgaul O. Glycobiology. 2008 Feb;18(2):187-94. doi: 10.1093/glycob/cwm132. Epub 2007 Dec 12. Glycobiology. 2008. PMID: 18077550 Free PMC article.
We found that ST8Sia-IV as well as ST8Sia-II and ST8Sia-III are inhibited by 2'-O-methyl CMP as robustly as by CMP and moderately by 5-methyl CMP. ...These results suggest that 2'-O-methyl CMP and 5-methyl CMP can be used to preferentially inhibit sialyltransferases, in particular, polysialyltransferases in vitro and in vivo. ...
We found that ST8Sia-IV as well as ST8Sia-II and ST8Sia-III are inhibited by 2'-O-methyl CMP as robustly as by CMP and moderately by …
6'-Sulfo sialyl Lex but not 6-sulfo sialyl Lex expressed on the cell surface supports L-selectin-mediated adhesion.
Tsuboi S, Isogai Y, Hada N, King JK, Hindsgaul O, Fukuda M. Tsuboi S, et al. Among authors: Hindsgaul O. J Biol Chem. 1996 Nov 1;271(44):27213-6. doi: 10.1074/jbc.271.44.27213. J Biol Chem. 1996. PMID: 8910289
., Hindsgaul, O., and Palcic, M. M. (1992) J. Biol. Chem. 267, 22356-22361). CHO cells were incubated with synthetic 6'-sulfo sialyl Lex, NeuNAcalpha2-->3(sulfate-6)Galbeta1-->4(Fucalpha1-->3) GlcNAc or 6-sulfo sialyl Lex, NeuNAcalpha2-->3Galbeta1-->4[(Fucalpha1-->3)sulfate--> 6GlcNAc] oligosaccharide linked to C-6 of a fucose residue in GDP-fucose and a milk fucosyltransferase. ...
., Hindsgaul, O., and Palcic, M. M. (1992) J. Biol. Chem. 267, 22356-22361). CHO cells were incubated with synthetic 6'-sulfo …
Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.
Akama TO, Nakayama J, Nishida K, Hiraoka N, Suzuki M, McAuliffe J, Hindsgaul O, Fukuda M, Fukuda MN. Akama TO, et al. Among authors: Hindsgaul O. J Biol Chem. 2001 May 11;276(19):16271-8. doi: 10.1074/jbc.M009995200. Epub 2001 Feb 15. J Biol Chem. 2001. PMID: 11278593
Human corneal N-acetylglucosamine 6-O-sulfotransferase (hCGn6ST) has been identified by the positional candidate approach as the gene responsible for macular corneal dystrophy (MCD). ...Moreover, mouse intestinal GlcNAc 6-O-sulfotransferase had the same activity as hCGn6ST. This observation suggests that mouse intestinal GlcNAc 6-O-sulfotransferase is the orthologue of hCGn6ST and functions as a sulfotransferase to produce keratan sulfate in the cornea....
Human corneal N-acetylglucosamine 6-O-sulfotransferase (hCGn6ST) has been identified by the positional candidate approach as the gene …
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