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Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase.
Shimada H, Hirai K, Simamura E, Hatta T, Iwakiri H, Mizuki K, Hatta T, Sawasaki T, Matsunaga S, Endo Y, Shimizu S. Shimada H, et al. J Biol Chem. 2009 Oct 16;284(42):28642-9. doi: 10.1074/jbc.M109.033431. Epub 2009 Aug 28. J Biol Chem. 2009. PMID: 19717555 Free PMC article.
Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel.
Simamura E, Hirai K, Shimada H, Koyama J, Niwa Y, Shimizu S. Simamura E, et al. Cancer Biol Ther. 2006 Nov;5(11):1523-9. doi: 10.4161/cbt.5.11.3302. Epub 2006 Nov 19. Cancer Biol Ther. 2006. PMID: 17012850
Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells.
Hirai KI, Koyama J, Pan J, Simamura E, Shimada H, Yamori T, Sato S, Tagahara K, Tsuruo T. Hirai KI, et al. Cancer Detect Prev. 1999;23(6):539-50. doi: 10.1046/j.1525-1500.1999.99052.x. Cancer Detect Prev. 1999. PMID: 10571665
Mitochondrial damage by a new antitumour agent furanonaphthoquinone derivative in human cervical cancer HeLa cells.
Pan J, Hirai KI, Simamura E, Koyama J, Shimada H, Kuwabara S. Pan J, et al. J Electron Microsc (Tokyo). 1997;46(2):181-7. doi: 10.1093/oxfordjournals.jmicro.a023506. J Electron Microsc (Tokyo). 1997. PMID: 9180033
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Shimada H, Furuno H, Hirai K, Koyama J, Ariyama J, Simamura E. Shimada H, et al. Arch Biochem Biophys. 2002 Jun 1;402(1):149-57. doi: 10.1016/S0003-9861(02)00059-0. Arch Biochem Biophys. 2002. PMID: 12051692
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