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1,243 results
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Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF.
Yamazaki Y, Hirai Y, Miyake K, Shimada T. Yamazaki Y, et al. Among authors: hirai y. Sci Rep. 2014 Jul 1;4:5506. doi: 10.1038/srep05506. Sci Rep. 2014. PMID: 24981028 Free PMC article.
Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector.
Hironaka K, Yamazaki Y, Hirai Y, Yamamoto M, Miyake N, Miyake K, Okada T, Morita A, Shimada T. Hironaka K, et al. Among authors: hirai y. Sci Rep. 2015 Aug 18;5:13104. doi: 10.1038/srep13104. Sci Rep. 2015. PMID: 26283284 Free PMC article.
Adeno-associated viral vector-mediated gene transduction in mesencephalic slice culture.
Nihira T, Yasuda T, Hirai Y, Shimada T, Mizuno Y, Mochizuki H. Nihira T, et al. Among authors: hirai y. J Neurosci Methods. 2011 Sep 30;201(1):55-60. doi: 10.1016/j.jneumeth.2011.07.010. Epub 2011 Jul 23. J Neurosci Methods. 2011. PMID: 21827789
Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles.
Mayra A, Tomimitsu H, Kubodera T, Kobayashi M, Piao W, Sunaga F, Hirai Y, Shimada T, Mizusawa H, Yokota T. Mayra A, et al. Among authors: hirai y. Biochem Biophys Res Commun. 2011 Feb 11;405(2):204-9. doi: 10.1016/j.bbrc.2011.01.009. Epub 2011 Jan 8. Biochem Biophys Res Commun. 2011. PMID: 21219850
Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.
Igarashi T, Miyake K, Kobayashi M, Kameya S, Fujimoto C, Nakamoto K, Takahashi H, Igarashi T, Miyake N, Iijima O, Hirai Y, Shimada T, Okada T, Takahashi H. Igarashi T, et al. Among authors: hirai y. Mol Vis. 2016 Jul 16;22:816-26. eCollection 2016. Mol Vis. 2016. PMID: 27440998 Free PMC article.
Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury.
Hirai T, Enomoto M, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M, Kuwahara H, Yamamoto M, Tajiri M, Miyata H, Hirai Y, Tominaga M, Shinomiya K, Mizusawa H, Okawa A, Yokota T. Hirai T, et al. Among authors: hirai y. Mol Ther. 2014 Feb;22(2):409-419. doi: 10.1038/mt.2013.247. Epub 2013 Oct 28. Mol Ther. 2014. PMID: 24322332 Free PMC article.
Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice.
Machida A, Kuwahara H, Mayra A, Kubodera T, Hirai T, Sunaga F, Tajiri M, Hirai Y, Shimada T, Mizusawa H, Yokota T. Machida A, et al. Among authors: hirai t, hirai y. Mol Pain. 2013 Jul 18;9:36. doi: 10.1186/1744-8069-9-36. Mol Pain. 2013. PMID: 23866078 Free PMC article.
Serotype-independent method of recombinant adeno-associated virus (AAV) vector production and purification.
Miyake K, Miyake N, Yamazaki Y, Shimada T, Hirai Y. Miyake K, et al. Among authors: hirai y. J Nippon Med Sch. 2012;79(6):394-402. doi: 10.1272/jnms.79.394. J Nippon Med Sch. 2012. PMID: 23291836 Review.
Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice.
Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, Hirai Y, Sotome S, Mizusawa H, Shinomiya K, Okawa A, Yokota T. Hirai T, et al. Among authors: hirai y. Hum Gene Ther Methods. 2012 Apr;23(2):119-27. doi: 10.1089/hgtb.2012.035. Epub 2012 May 14. Hum Gene Ther Methods. 2012. PMID: 22583159
Direct comparison of four adeno-associated virus serotypes in mediating the production of antiangiogenic proteins in mouse muscle.
Isotani M, Miyake K, Miyake N, Hirai Y, Shimada T. Isotani M, et al. Among authors: hirai y. Cancer Invest. 2011 Jun;29(5):353-9. doi: 10.3109/07357907.2011.584585. Cancer Invest. 2011. PMID: 21599511
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