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Showing results for hirbo jibril[Author]
Your search for HirboJibril[Author] retrieved no results
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
White SL, Brasher MS, Pattee J, Zhou W, Chapman S, Jee YH, Bell CC, Jamil TL, Barrio M, Arehart CH, Evans LM, Hirbo J, Cox NJ, Straub P, Namba S, Bertucci-Richter E, Guare L, Edris A, Morris S, Mulford AJ, Zhang H, Fennessy B, Tobin MD, Chen J, Williams AT, John C, van Heel DA, Mathur R, Finer S, Moksnes MR, Brumpton BM, Åsvold BO, Peculis R, Rovite V, Konrade I, Wang Y, Crooks K, Chavan S, Fisher MJ, Rafaels N, Lin M, Shortt JA, Sanders AR, Whiteman DC, MacGregor S, Medland SE, Thorsteinsdóttir U, Stefánsson K, Karaderi T, Egan KM, Bocklage T, McCrary HC, Riedlinger G, Salhia B, Shriver C, Phan MD, Farlow JL, Edge S, Kaur V, Churchman ML, Rounbehler RJ, Brock PL, Ringel MD, Pividori M, Schweppe R, Raeburn CD, Walters RG, Chen Z, Li L, Matsuda K, Okada Y, Zöllner S, Verma A; Penn Medicine BioBank; Preuss MH, Kenny E, Hendricks AE, Fishbein L, Kraft P, Daly MJ, Neale BM; Virtual Thyroid Biopsy Consortium; Colorado Center for Personalized Medicine; Genes & Health Research Team; BioBank Japan Project; Martin AR, Cole JB, Haugen BR; Global Biobank Meta-analysis Initiative; Gignoux CR, Pozdeyev N. White SL, et al. Among authors: hirbo j. Nat Genet. 2026 Feb;58(2):307-316. doi: 10.1038/s41588-025-02483-w. Epub 2026 Feb 5. Nat Genet. 2026. PMID: 41644669 Free PMC article.
Recommendations for responsible use of population descriptors in polygenic risk score development.
Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR, Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL; Polygenic Risk Methods Development (PRIMED) Consortium; Sun Q. Smith JL, et al. Among authors: hirbo jb. Nat Genet. 2025 Dec;57(12):2962-2971. doi: 10.1038/s41588-025-02395-9. Epub 2025 Nov 24. Nat Genet. 2025. PMID: 41286102 Free PMC article. Review.
Genome sequencing of 35,024 predominantly African ancestry persons addresses gaps in genomics and healthcare.
Avery C, Babanejad M, Baker J, Bledsoe X, Blostein F, Corty RW, Ellis K, Hung AM, Lake A, Shelley J, Sheng Q; Vanderbilt University Medical Center and Alliance for Genomic Discovery Investigators; Aldrich M, Basford M, Bastarache L, Below J, Bick AG, Embi P, Feng Q, Gamazon E, Han L, Hirbo J, Marginean K, Mosley J, Pulley J, Roden DM, Ruderfer DM, Shuey M, Shyr Y, Stein CM, Walsh C, Wilkins C. Avery C, et al. Among authors: hirbo j. medRxiv [Preprint]. 2025 Nov 2:2025.10.30.25338549. doi: 10.1101/2025.10.30.25338549. medRxiv. 2025. PMID: 41282679 Free PMC article. Preprint.
A data model for population descriptors in genomic research.
Khan AT, Adebamowo C, Fullerton SM, Hirbo J, Konigsberg IR, Kraft P, Martin I, Nelson SC, Ramsay M, Wojcik GL, Adebamowo SN, Conomos MP, Darst BF, Hysong MR, Li Y, Martin AR, Mathias RA, Rich SS, Sakoda LC, Schrider DR, Sharma J, Smith JL, Sun Q, Zhang Y; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium; Gogarten SM. Khan AT, et al. Among authors: hirbo j. Am J Hum Genet. 2025 Jul 3;112(7):1504-1514. doi: 10.1016/j.ajhg.2025.05.011. Epub 2025 Jun 12. Am J Hum Genet. 2025. PMID: 40513563 Free PMC article. Review.
On the relationship between genes and environment.
Hirbo JB, Were MC, Jones-Paris CR. Hirbo JB, et al. Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2510804122. doi: 10.1073/pnas.2510804122. Epub 2025 Jun 13. Proc Natl Acad Sci U S A. 2025. PMID: 40512726 Free PMC article. No abstract available.
Global multi-ancestry genetic study elucidates genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
White SL, Brasher MS, Pattee J, Zhou W, Chapman S, Jee YH, Bell CC, Jamil TL, Barrio M, Hirbo J, Cox NJ, Straub P, Namba S, Bertucci-Richter E, Guare L, EdrisMohammed A, Morris S, Mulford AJ, Zhang H, Fennessy B, Tobin MD, Chen J, Williams AT, John C, van Heel DA, Mathur R, Finer S, Moksnes MR, Brumpton B, Åsvold BO, Peculis R, Rovite V, Konrade I, Wang Y, Crooks K, Chavan S, Fisher MJ, Rafaels N, Lin M, Shortt J, Sanders AR, Whiteman D, MacGregor S, Medland S, Thorsteinsdóttir U, Stefánsson K, Karaderi T, Egan KM, Bocklage T, McCrary HC, Riedlingeer G, Salhia B, Shriver C, Phan MD, Farlow JL, Edge S, Kaur V, Churchman M, Rounbehler RJ, Brock PL, Ringel MD, Pividori M, Schweppe R, Raeburn CD, Walters R, Chen Z, Li L, Matsuda K, Okada Y, Zoellner S, Verma A, Preuss M, Kenny E, Hendricks A, Fishbein L, Kraft P, Daly M, Neale B; biobank at the Colorado Center for Personalized Medicine; Genes & Health Research Team; BioBank Japan Project; Martin A, Cole JB, Haugen BR, Gignoux CR, Pozdeyev N. White SL, et al. Among authors: hirbo j. medRxiv [Preprint]. 2025 May 16:2025.05.15.25327513. doi: 10.1101/2025.05.15.25327513. medRxiv. 2025. Update in: Nat Genet. 2026 Feb;58(2):307-316. doi: 10.1038/s41588-025-02483-w. PMID: 40463558 Free PMC article. Updated. Preprint.
Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer.
Rajagopal PS, Reid S, Fan R, Venton L, Weidner A, Roberson ML, Vadaparampil S, Wang X, Yoder S, Rosa M, Sanders M, Gonzalez-Ericsson P, Hirbo J, Whisenant JG, Pietenpol J, Ye F, Pal T, Lehmann BD. Rajagopal PS, et al. Among authors: hirbo j. NPJ Breast Cancer. 2025 Mar 11;11(1):28. doi: 10.1038/s41523-025-00731-0. NPJ Breast Cancer. 2025. PMID: 40069179 Free PMC article.
West African Genetic Ancestry and Breast Cancer Outcomes Among Black Women.
Reid S, Fan R, Venton L, Weidner A, Tezak A, Roberson ML, Vadaparampil S, Wang X, Yoder S, Rosa M, Hirbo J, Whisenant JG, Pietenpol J, Rajagopal PS, Lehmann B, Ye F, Pal T. Reid S, et al. Among authors: hirbo j. JAMA Netw Open. 2024 Dec 2;7(12):e2449798. doi: 10.1001/jamanetworkopen.2024.49798. JAMA Netw Open. 2024. PMID: 39652347 Free PMC article.
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations.
Hou K, Gogarten S, Kim J, Hua X, Dias JA, Sun Q, Wang Y, Tan T; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Atkinson EG, Martin A, Shortt J, Hirbo J, Li Y, Pasaniuc B, Zhang H. Hou K, et al. Among authors: hirbo j. Bioinformatics. 2024 Mar 29;40(4):btae148. doi: 10.1093/bioinformatics/btae148. Bioinformatics. 2024. PMID: 38490256 Free PMC article.
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.
Lo Faro V, Bhattacharya A, Zhou W, Zhou D, Wang Y, Läll K, Kanai M, Lopera-Maya E, Straub P, Pawar P, Tao R, Zhong X, Namba S; Global Biobank Meta-analysis Initiative; Sanna S, Nolte IM, Okada Y, Ingold N, MacGregor S, Snieder H, Surakka I, Shortt J, Gignoux C, Rafaels N, Crooks K, Verma A, Verma SS, Guare L, Rader DJ, Willer C, Martin AR, Brantley MA Jr, Gamazon ER, Jansonius NM, Joos K, Cox NJ, Hirbo J. Lo Faro V, et al. Among authors: hirbo j. Cell Rep Med. 2024 Feb 20;5(2):101430. doi: 10.1016/j.xcrm.2024.101430. Cell Rep Med. 2024. PMID: 38382466 Free PMC article.
Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations.
Hou K, Gogarten S, Kim J, Hua X, Dias JA, Sun Q, Wang Y, Tan T; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Atkinson EG, Martin A, Shortt J, Hirbo J, Li Y, Pasaniuc B, Zhang H. Hou K, et al. Among authors: hirbo j. bioRxiv [Preprint]. 2023 Oct 2:2023.09.30.560263. doi: 10.1101/2023.09.30.560263. bioRxiv. 2023. Update in: Bioinformatics. 2024 Mar 29;40(4):btae148. doi: 10.1093/bioinformatics/btae148. PMID: 37873338 Free PMC article. Updated. Preprint.
Principles and methods for transferring polygenic risk scores across global populations.
Kachuri L, Chatterjee N, Hirbo J, Schaid DJ, Martin I, Kullo IJ, Kenny EE, Pasaniuc B; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Witte JS, Ge T. Kachuri L, et al. Among authors: hirbo j. Nat Rev Genet. 2024 Jan;25(1):8-25. doi: 10.1038/s41576-023-00637-2. Epub 2023 Aug 24. Nat Rev Genet. 2024. PMID: 37620596 Free PMC article. Review.
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation.
Fan S, Spence JP, Feng Y, Hansen MEB, Terhorst J, Beltrame MH, Ranciaro A, Hirbo J, Beggs W, Thomas N, Nyambo T, Mpoloka SW, Mokone GG, Njamnshi A, Folkunang C, Meskel DW, Belay G, Song YS, Tishkoff SA. Fan S, et al. Among authors: hirbo j. Cell. 2023 Mar 2;186(5):923-939.e14. doi: 10.1016/j.cell.2023.01.042. Cell. 2023. PMID: 36868214 Free PMC article.
The genetic and evolutionary basis of gene expression variation in East Africans.
Kelly DE, Ramdas S, Ma R, Rawlings-Goss RA, Grant GR, Ranciaro A, Hirbo JB, Beggs W, Yeager M, Chanock S, Nyambo TB, Omar SA, Woldemeskel D, Belay G, Li H, Brown CD, Tishkoff SA. Kelly DE, et al. Among authors: hirbo jb. Genome Biol. 2023 Feb 24;24(1):35. doi: 10.1186/s13059-023-02874-4. Genome Biol. 2023. PMID: 36829244 Free PMC article.
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics.
Partanen JJ, Häppölä P, Zhou W, Lehisto AA, Ainola M, Sutinen E, Allen RJ, Stockwell AD, Leavy OC, Oldham JM, Guillen-Guio B, Cox NJ, Hirbo JB, Schwartz DA, Fingerlin TE, Flores C, Noth I, Yaspan BL, Jenkins RG, Wain LV, Ripatti S, Pirinen M; International IPF Genetics Consortium; Global Biobank Meta-Analysis Initiative (GBMI); Laitinen T, Kaarteenaho R, Myllärniemi M, Daly MJ, Koskela JT. Partanen JJ, et al. Among authors: hirbo jb. Cell Genom. 2022 Oct 12;2(10):100181. doi: 10.1016/j.xgen.2022.100181. eCollection 2022 Oct 12. Cell Genom. 2022. PMID: 36777997 Free PMC article.
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.
Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, O… See abstract for full author list ➔ Zhou W, et al. Among authors: hirbo jb. Cell Genom. 2022 Oct 12;2(10):100192. doi: 10.1016/j.xgen.2022.100192. eCollection 2022 Oct 12. Cell Genom. 2022. PMID: 36777996 Free PMC article.
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.
Wang Y, Namba S, Lopera E, Kerminen S, Tsuo K, Läll K, Kanai M, Zhou W, Wu KH, Favé MJ, Bhatta L, Awadalla P, Brumpton B, Deelen P, Hveem K, Lo Faro V, Mägi R, Murakami Y, Sanna S, Smoller JW, Uzunovic J, Wolford BN; Global Biobank Meta-analysis Initiative; Willer C, Gamazon ER, Cox NJ, Surakka I, Okada Y, Martin AR, Hirbo J. Wang Y, et al. Among authors: hirbo j. Cell Genom. 2023 Jan 4;3(1):100241. doi: 10.1016/j.xgen.2022.100241. eCollection 2023 Jan 11. Cell Genom. 2023. PMID: 36777179 Free PMC article.
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.
Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Wata Mpoloka S, George Mokone G; Regeneron Genetic Center; Nyambo T, Wolde Meskel D, Belay G, Fokunang C, Njamnshi AK, Omar SA, Williams SM, Rader DJ, Ritchie MD, de la Fuente-Nunez C, Sirugo G, Tishkoff SA. Zhang C, et al. Among authors: hirbo j. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123000119. doi: 10.1073/pnas.2123000119. Epub 2022 May 17. Proc Natl Acad Sci U S A. 2022. PMID: 35580180 Free PMC article.
Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.
Zhang C, Verma A, Feng Y, Dos Reis Melo MC, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel M, Campbell M, Beggs W, Hirbo J, Mpoloka SW, Mokone GG, Jones M, Nyambo T, Meskel DW, Belay G, Fokunang C, Njamnshi A, Omar S, Williams S, Rader D, Ritchie M, de la Fuente C, Sirugo G, Tishkoff S. Zhang C, et al. Among authors: hirbo j. Res Sq [Preprint]. 2021 Jul 27:rs.3.rs-673011. doi: 10.21203/rs.3.rs-673011/v1. Res Sq. 2021. Update in: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123000119. doi: 10.1073/pnas.2123000119. PMID: 34341784 Free PMC article. Updated. Preprint.
Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.
Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Mpoloka SW, Mokone GG; Regeneron Genetic Center; Nyambo T, Meskel DW, Belay G, Fokunang C, Njamnshi AK, Omar SA, Williams SM, Rader D, Ritchie MD, de la Fuente Nunez C, Sirugo G, Tishkoff S. Zhang C, et al. Among authors: hirbo j. medRxiv [Preprint]. 2021 Aug 7:2021.06.28.21259529. doi: 10.1101/2021.06.28.21259529. medRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123000119. doi: 10.1073/pnas.2123000119. PMID: 34230933 Free PMC article. Updated. Preprint.
Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.
Scheinfeldt LB, Soi S, Lambert C, Ko WY, Coulibaly A, Ranciaro A, Thompson S, Hirbo J, Beggs W, Ibrahim M, Nyambo T, Omar S, Woldemeskel D, Belay G, Froment A, Kim J, Tishkoff SA. Scheinfeldt LB, et al. Among authors: hirbo j. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4166-4175. doi: 10.1073/pnas.1817678116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782801 Free PMC article. Clinical Trial.
Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.
Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A. Hansen ME, et al. Among authors: hirbo j. Hum Mol Genet. 2016 Jun 1;25(11):2324-2330. doi: 10.1093/hmg/ddw070. Epub 2016 Mar 2. Hum Mol Genet. 2016. PMID: 26936823 Free PMC article.
GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes.
Kim M, Cooper BA, Venkat R, Phillips JB, Eidem HR, Hirbo J, Nutakki S, Williams SM, Muglia LJ, Capra JA, Petren K, Abbot P, Rokas A, McGary KL. Kim M, et al. Among authors: hirbo j. Nucleic Acids Res. 2016 Jan 4;44(D1):D908-16. doi: 10.1093/nar/gkv1137. Epub 2015 Nov 14. Nucleic Acids Res. 2016. PMID: 26567549 Free PMC article.
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Campbell MC, et al. Among authors: hirbo j. J Hum Genet. 2014 Jun;59(6):349-52. doi: 10.1038/jhg.2014.29. Epub 2014 May 1. J Hum Genet. 2014. PMID: 24785689 Free PMC article.
Genetic origins of lactase persistence and the spread of pastoralism in Africa.
Ranciaro A, Campbell MC, Hirbo JB, Ko WY, Froment A, Anagnostou P, Kotze MJ, Ibrahim M, Nyambo T, Omar SA, Tishkoff SA. Ranciaro A, et al. Among authors: hirbo jb. Am J Hum Genet. 2014 Apr 3;94(4):496-510. doi: 10.1016/j.ajhg.2014.02.009. Epub 2014 Mar 13. Am J Hum Genet. 2014. PMID: 24630847 Free PMC article.
Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Campbell MC, et al. Among authors: hirbo j. Mol Biol Evol. 2014 Feb;31(2):288-302. doi: 10.1093/molbev/mst211. Epub 2013 Oct 30. Mol Biol Evol. 2014. PMID: 24177185 Free PMC article.
Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.
Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Ko WY, et al. Among authors: hirbo jb. Am J Hum Genet. 2011 Jun 10;88(6):741-754. doi: 10.1016/j.ajhg.2011.05.005. Am J Hum Genet. 2011. PMID: 21664997 Free PMC article.
The genetic structure and history of Africans and African Americans.
Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, Ibrahim M, Juma AT, Kotze MJ, Lema G, Moore JH, Mortensen H, Nyambo TB, Omar SA, Powell K, Pretorius GS, Smith MW, Thera MA, Wambebe C, Weber JL, Williams SM. Tishkoff SA, et al. Among authors: hirbo jb. Science. 2009 May 22;324(5930):1035-44. doi: 10.1126/science.1172257. Epub 2009 Apr 30. Science. 2009. PMID: 19407144 Free PMC article.
Convergent adaptation of human lactase persistence in Africa and Europe.
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Tishkoff SA, et al. Among authors: hirbo jb. Nat Genet. 2007 Jan;39(1):31-40. doi: 10.1038/ng1946. Epub 2006 Dec 10. Nat Genet. 2007. PMID: 17159977 Free PMC article.