Hiriyanna S - Search Results

1

Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice.

Marangoni D, Bush RA, Zeng Y, Wei LL, Ziccardi L, Vijayasarathy C, Bartoe JT, Palyada K, Santos M, Hiriyanna S, Wu Z, Colosi P, Sieving PA. Marangoni D, et al. Among authors: hiriyanna s. Mol Ther Methods Clin Dev. 2016 Mar 16;5:16011. doi: 10.1038/mtm.2016.11. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27626041 Free PMC article.

2

Remapping of the RP15 locus for X-linked cone-rod degeneration to Xp11.4-p21.1, and identification of a de novo insertion in the RPGR exon ORF15.

Mears AJ, Hiriyanna S, Vervoort R, Yashar B, Gieser L, Fahrner S, Daiger SP, Heckenlively JR, Sieving PA, Wright AF, Swaroop A. Mears AJ, et al. Among authors: hiriyanna s. Am J Hum Genet. 2000 Oct;67(4):1000-3. doi: 10.1086/303091. Epub 2000 Sep 1. Am J Hum Genet. 2000. PMID: 10970770 Free PMC article.

3

Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15.

Thompson DA, Khan NW, Othman MI, Chang B, Jia L, Grahek G, Wu Z, Hiriyanna S, Nellissery J, Li T, Khanna H, Colosi P, Swaroop A, Heckenlively JR. Thompson DA, et al. Among authors: hiriyanna s. PLoS One. 2012;7(5):e35865. doi: 10.1371/journal.pone.0035865. Epub 2012 May 1. PLoS One. 2012. PMID: 22563472 Free PMC article.

4

Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits.

Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA. Marangoni D, et al. Among authors: hiriyanna s. Hum Gene Ther Clin Dev. 2014 Dec;25(4):202-11. doi: 10.1089/humc.2014.067. Hum Gene Ther Clin Dev. 2014. PMID: 25211193 Free PMC article.

5

A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration.

Wu Z, Hiriyanna S, Qian H, Mookherjee S, Campos MM, Gao C, Fariss R, Sieving PA, Li T, Colosi P, Swaroop A. Wu Z, et al. Among authors: hiriyanna s. Hum Mol Genet. 2015 Jul 15;24(14):3956-70. doi: 10.1093/hmg/ddv134. Epub 2015 Apr 15. Hum Mol Genet. 2015. PMID: 25877300 Free PMC article.

6

Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy.

Mookherjee S, Hiriyanna S, Kaneshiro K, Li L, Li Y, Li W, Qian H, Li T, Khanna H, Colosi P, Swaroop A, Wu Z. Mookherjee S, et al. Among authors: hiriyanna s. Hum Mol Genet. 2015 Nov 15;24(22):6446-58. doi: 10.1093/hmg/ddv354. Epub 2015 Sep 10. Hum Mol Genet. 2015. PMID: 26358772 Free PMC article.

7

Preclinical Dose-Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function.

Bush RA, Zeng Y, Colosi P, Kjellstrom S, Hiriyanna S, Vijayasarathy C, Santos M, Li J, Wu Z, Sieving PA. Bush RA, et al. Among authors: hiriyanna s. Hum Gene Ther. 2016 May;27(5):376-89. doi: 10.1089/hum.2015.142. Hum Gene Ther. 2016. PMID: 27036983 Free PMC article.

8

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography.

Zeng Y, Petralia RS, Vijayasarathy C, Wu Z, Hiriyanna S, Song H, Wang YX, Sieving PA, Bush RA. Zeng Y, et al. Among authors: hiriyanna s. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT277-87. doi: 10.1167/iovs.15-18920. Invest Ophthalmol Vis Sci. 2016. PMID: 27409484 Free PMC article.

9

Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice.

Yu W, Mookherjee S, Chaitankar V, Hiriyanna S, Kim JW, Brooks M, Ataeijannati Y, Sun X, Dong L, Li T, Swaroop A, Wu Z. Yu W, et al. Among authors: hiriyanna s. Nat Commun. 2017 Mar 14;8:14716. doi: 10.1038/ncomms14716. Nat Commun. 2017. PMID: 28291770 Free PMC article.

10

Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.

Cukras C, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Park TK, Hiriyanna S, Wright JF, Colosi P, Wu Z, Bush RA, Wei LL, Sieving PA. Cukras C, et al. Among authors: hiriyanna s. Mol Ther. 2018 Sep 5;26(9):2282-2294. doi: 10.1016/j.ymthe.2018.05.025. Epub 2018 Jul 7. Mol Ther. 2018. PMID: 30196853 Free PMC article. Clinical Trial.

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