Hirsch AK - Search Results

1

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

Masini T, Hirsch AK. Masini T, et al. Among authors: hirsch ak. J Med Chem. 2014 Dec 11;57(23):9740-63. doi: 10.1021/jm5010978. Epub 2014 Sep 25. J Med Chem. 2014. PMID: 25210872 Review.

2

Druggability of the enzymes of the non-mevalonate-pathway.

Masini T, Kroezen BS, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Drug Discov Today. 2013 Dec;18(23-24):1256-62. doi: 10.1016/j.drudis.2013.07.003. Epub 2013 Jul 13. Drug Discov Today. 2013. PMID: 23856326 Review.

3

Combinatorial screening for specific drug solubilizers with switchable release profiles.

Wieczorek S, Vigne S, Masini T, Ponader D, Hartmann L, Hirsch AK, Börner HG. Wieczorek S, et al. Among authors: hirsch ak. Macromol Biosci. 2015 Jan;15(1):82-9. doi: 10.1002/mabi.201400443. Epub 2014 Dec 29. Macromol Biosci. 2015. PMID: 25557786

4

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors.

Huizing AP, Mondal M, Hirsch AK. Huizing AP, et al. Among authors: hirsch ak. J Med Chem. 2015 Jul 9;58(13):5151-63. doi: 10.1021/jm5014133. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25719272

5

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28. Org Biomol Chem. 2015. PMID: 26411373

6

Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets.

Monjas L, Hirsch AK. Monjas L, et al. Among authors: hirsch ak. Future Med Chem. 2015;7(16):2095-8. doi: 10.4155/fmc.15.146. Epub 2015 Oct 29. Future Med Chem. 2015. PMID: 26510895 No abstract available.

7

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E. Masini T, et al. Among authors: hirsch ak. J Enzyme Inhib Med Chem. 2016;31(sup4):170-175. doi: 10.1080/14756366.2016.1201812. Epub 2016 Jul 19. J Enzyme Inhib Med Chem. 2016. PMID: 27435185 Free PMC article.

8

Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy.

Wieczorek S, Remmler D, Masini T, Kochovski Z, Hirsch AK, Börner HG. Wieczorek S, et al. Among authors: hirsch ak. Bioconjug Chem. 2017 Mar 15;28(3):760-767. doi: 10.1021/acs.bioconjchem.6b00549. Epub 2017 Jan 13. Bioconjug Chem. 2017. PMID: 28002941

9

Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3.

Hartman AM, Hirsch AKH. Hartman AM, et al. Eur J Med Chem. 2017 Aug 18;136:573-584. doi: 10.1016/j.ejmech.2017.04.058. Epub 2017 Apr 24. Eur J Med Chem. 2017. PMID: 28549334 Review.

10

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

Nasti R, Rossi D, Amadio M, Pascale A, Unver MY, Hirsch AKH, Collina S. Nasti R, et al. J Med Chem. 2017 Oct 26;60(20):8257-8267. doi: 10.1021/acs.jmedchem.6b01871. Epub 2017 Jun 19. J Med Chem. 2017. PMID: 28587461

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