Hirschmann R - Search Results

1

Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor.

Foister S, Taylor LL, Feng JJ, Chen WL, Lin A, Cheng FC, Smith AB 3rd, Hirschmann R. Foister S, et al. Among authors: hirschmann r. Org Lett. 2006 Apr 27;8(9):1799-802. doi: 10.1021/ol060278h. Org Lett. 2006. PMID: 16623554

2

Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics.

Smith AB 3rd, Charnley AK, Mesaros EF, Kikuchi O, Wang W, Benowitz A, Chu CL, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Org Lett. 2005 Feb 3;7(3):399-402. doi: 10.1021/ol0476974. Org Lett. 2005. PMID: 15673249

3

Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1.

Angeles AR, Neagu I, Birzin ET, Thornton ER, Smith AB 3rd, Hirschmann R. Angeles AR, et al. Among authors: hirschmann r. Org Lett. 2005 Mar 17;7(6):1121-4. doi: 10.1021/ol050119i. Org Lett. 2005. PMID: 15760154

4

Catechol: A minimal scaffold for non-peptide peptidomimetics of the i + 1 and i + 2 positions of the beta-turn of somatostatin.

Mowery BP, Prasad V, Kenesky CS, Angeles AR, Taylor LL, Feng JJ, Chen WL, Lin A, Cheng FC, Smith AB 3rd, Hirschmann R. Mowery BP, et al. Among authors: hirschmann r. Org Lett. 2006 Sep 28;8(20):4397-400. doi: 10.1021/ol061488x. Org Lett. 2006. PMID: 16986909

5

A second-generation synthesis of polypyrrolinone nonpeptidomimetics: prelude to the synthesis of polypyrrolinones on solid support.

Smith AB 3rd, Liu H, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Org Lett. 2000 Jul 13;2(14):2037-40. doi: 10.1021/ol0059293. Org Lett. 2000. PMID: 10891224

6

Design and synthesis of novel scaffolds for drug discovery: hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines.

Abrous L, Hynes J Jr, Friedrich SR, Smith AB 3rd, Hirschmann R. Abrous L, et al. Among authors: hirschmann r. Org Lett. 2001 Apr 5;3(7):1089-92. doi: 10.1021/ol015698f. Org Lett. 2001. PMID: 11277802

7

First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.

Smith AB 3rd, Cho YS, Zawacki LE, Hirschmann R, Pettit GR. Smith AB 3rd, et al. Among authors: hirschmann r. Org Lett. 2001 Dec 13;3(25):4063-6. doi: 10.1021/ol016799g. Org Lett. 2001. PMID: 11735585

8

Investigation of an antibody-ligase. Evidence for strain-induced catalysis.

Savinov SN, Hirschmann R, Benkovic SJ, Smith AB 3rd. Savinov SN, et al. Among authors: hirschmann r. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1321-4. doi: 10.1016/s0960-894x(03)00123-9. Bioorg Med Chem Lett. 2003. PMID: 12657273

9

Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.

Neelamkavil S, Arison B, Birzin E, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Thornton ER, Smith AB 3rd, Hirschmann R. Neelamkavil S, et al. Among authors: hirschmann r. J Med Chem. 2005 Jun 16;48(12):4025-30. doi: 10.1021/jm058184l. J Med Chem. 2005. PMID: 15943475

10

Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes.

Smith AB 3rd, Wang W, Charnley AK, Carroll PJ, Kenesky CS, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Org Lett. 2010 Jul 2;12(13):2990-3. doi: 10.1021/ol101007n. Org Lett. 2010. PMID: 20518540 Free PMC article.

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