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Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G. Cui L, et al. Among authors: hitchcock is. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2017849118. doi: 10.1073/pnas.2017849118. Proc Natl Acad Sci U S A. 2021. PMID: 33384332 Free PMC article.
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J. Wilmes S, et al. Among authors: hitchcock is. Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242. Science. 2020. PMID: 32029621 Free PMC article.
Novel ET mutations: stuck in the MPL with you.
Hitchcock IS. Hitchcock IS. Blood. 2020 Mar 19;135(12):889-890. doi: 10.1182/blood.2020005000. Blood. 2020. PMID: 32191801 Free article. No abstract available.
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Tsutsumi N, et al. Among authors: hitchcock is. Cell. 2023 Sep 14;186(19):4189-4203.e22. doi: 10.1016/j.cell.2023.07.037. Epub 2023 Aug 25. Cell. 2023. PMID: 37633268 Free article.
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.
Saur SJ, Sangkhae V, Geddis AE, Kaushansky K, Hitchcock IS. Saur SJ, et al. Among authors: hitchcock is. Blood. 2010 Feb 11;115(6):1254-63. doi: 10.1182/blood-2009-06-227033. Epub 2009 Oct 30. Blood. 2010. PMID: 19880496 Free PMC article.
32 results