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Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B.
Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A. Sugimoto N, et al. Among authors: hitomi y. Nutr Cancer. 2014;66(3):419-23. doi: 10.1080/01635581.2013.877497. Epub 2014 Feb 18. Nutr Cancer. 2014. PMID: 24547961
Long-term heat exposure prevents hypoxia-induced apoptosis in mouse fibroblast cells.
Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H. Sugimoto N, et al. Among authors: hitomi y. Cell Biochem Biophys. 2014 Sep;70(1):301-7. doi: 10.1007/s12013-014-9912-9. Cell Biochem Biophys. 2014. PMID: 24648161
Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells.
Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H. Sugimoto N, et al. Among authors: hitomi y. Cell Physiol Biochem. 2012;30(2):450-7. doi: 10.1159/000339038. Epub 2012 Jul 6. Cell Physiol Biochem. 2012. PMID: 22814242
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