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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1976 4
1977 4
1978 7
1979 14
1980 8
1981 18
1982 8
1983 17
1984 19
1985 23
1986 14
1987 16
1988 16
1989 12
1990 23
1991 26
1992 22
1993 29
1994 52
1995 40
1996 45
1997 48
1998 45
1999 48
2000 55
2001 62
2002 65
2003 79
2004 105
2005 93
2006 119
2007 204
2008 235
2009 302
2010 334
2011 434
2012 488
2013 566
2014 612
2015 726
2016 729
2017 757
2018 829
2019 873
2020 991
2021 1050
2022 942
2023 892
2024 849
2025 1034
2026 558

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12,905 results

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Page 1
Extracellular HMGB1 as a proinflammatory cytokine.
Chen G, Ward MF, Sama AE, Wang H. Chen G, et al. J Interferon Cytokine Res. 2004 Jun;24(6):329-33. doi: 10.1089/107999004323142187. J Interferon Cytokine Res. 2004. PMID: 15212706 Review.
High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indi …
High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for …
Dealing with death: HMGB1 as a novel target for cancer therapy.
Lotze MT, DeMarco RA. Lotze MT, et al. Curr Opin Investig Drugs. 2003 Dec;4(12):1405-9. Curr Opin Investig Drugs. 2003. PMID: 14763124 Review.
High mobility group B1 (HMGB1) and its counter-receptor, receptor for advanced glycation end products (RAGE), represent suitable targets for investigation, integrating many aspects of modern biology, particularly that associated with chronic diseases involving inflammation …
High mobility group B1 (HMGB1) and its counter-receptor, receptor for advanced glycation end products (RAGE), represent suitable targ …
Pharmacological intervention of the HMGB1-pCTS-L axis to ameliorate inflammatory diseases.
Chen W, Li J, Qiang X, Lou L, Zhu CS, Deng M, Wang H. Chen W, et al. Front Immunol. 2026 May 8;17:1843251. doi: 10.3389/fimmu.2026.1843251. eCollection 2026. Front Immunol. 2026. PMID: 42183262 Free PMC article. Review.
Crucially, we highlight the newly established HMGB1-pCTS-L axis, in which HMGB1 directly upregulates pCTS-L expression and release. ...Furthermore, we explore the intricate role of tetranectin (TN), an endogenous HMGB1-binding protein, which inhibits HMGB1 …
Crucially, we highlight the newly established HMGB1-pCTS-L axis, in which HMGB1 directly upregulates pCTS-L expression and rel …
RAGE as a receptor of HMGB1 (Amphoterin): roles in health and disease.
Rauvala H, Rouhiainen A. Rauvala H, et al. Curr Mol Med. 2007 Dec;7(8):725-34. doi: 10.2174/156652407783220750. Curr Mol Med. 2007. PMID: 18331230 Review.
HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. ...This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we d …
HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by …
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis.
Li J, Zhu CS, He L, Qiang X, Chen W, Wang H. Li J, et al. Expert Opin Ther Targets. 2023 Jul-Dec;27(7):575-591. doi: 10.1080/14728222.2023.2239495. Epub 2023 Jul 25. Expert Opin Ther Targets. 2023. PMID: 37477229 Free PMC article. Review.
AREAS COVERED: Here we review our recent progress in searching for late-acting mediators of experimental sepsis and propose high mobility group box 1 (HMGB1) and procathepsin-L (pCTS-L) as potential therapeutic targets for improving outcomes of lethal sepsis and other infe …
AREAS COVERED: Here we review our recent progress in searching for late-acting mediators of experimental sepsis and propose high mobility gr …
HMGB1: An immmune odyssey.
Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P. Dumitriu IE, et al. Discov Med. 2005 Aug;5(28):388-92. Discov Med. 2005. PMID: 20704878 Free article.
One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein. Over the years, HMGB1 has been known by many names (amphoterin, differentiation enhancing factor, sulphoglucuronyl carbohy …
One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) prote …
HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish.
Fang P, Pan HC, Lin SL, Zhang WQ, Rauvala H, Schachner M, Shen YQ. Fang P, et al. Mol Neurobiol. 2014 Feb;49(1):472-83. doi: 10.1007/s12035-013-8533-4. Epub 2013 Aug 31. Mol Neurobiol. 2014. PMID: 23996344
High mobility group box 1 (HMGB1, also called amphoterin) facilitates neurite outgrowth in early development, yet can exacerbate pathology and inhibit regeneration by inducing adverse neuroinflammation when released from dying cells, suggesting that HMGB1 pla …
High mobility group box 1 (HMGB1, also called amphoterin) facilitates neurite outgrowth in early development, yet can exacerba …
RAGE-mediated cell signaling.
Rouhiainen A, Kuja-Panula J, Tumova S, Rauvala H. Rouhiainen A, et al. Methods Mol Biol. 2013;963:239-63. doi: 10.1007/978-1-62703-230-8_15. Methods Mol Biol. 2013. PMID: 23296615 Review.
RAGE binds AGEs (advanced glycation end products), HMGB1 (high-mobility group box-1; also designated as amphoterin), members of the S100 protein family, glycosaminoglycans and amyloid beta peptides. ...
RAGE binds AGEs (advanced glycation end products), HMGB1 (high-mobility group box-1; also designated as amphoterin), members o …
HMGB1 Inhibition During Zymosan-Induced Inflammation: The Potential Therapeutic Action of Riboflavin.
Mazur-Bialy AI, Pocheć E. Mazur-Bialy AI, et al. Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):171-6. doi: 10.1007/s00005-015-0366-6. Epub 2015 Oct 7. Arch Immunol Ther Exp (Warsz). 2016. PMID: 26445809 Free PMC article.
One of the factors responsible for the excessive intensification of the inflammatory response in the course of inflammation is high-mobility group protein B1 (HMGB1). HMG-1 is a nuclear protein which, after being released to the intercellular space, has a hig …
One of the factors responsible for the excessive intensification of the inflammatory response in the course of inflammation is high-mobility …
HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity.
Ciucci A, Gabriele I, Percario ZA, Affabris E, Colizzi V, Mancino G. Ciucci A, et al. PLoS One. 2011;6(8):e23766. doi: 10.1371/journal.pone.0023766. Epub 2011 Aug 22. PLoS One. 2011. PMID: 21915243 Free PMC article.
These are collectively known as damage-associated molecular-pattern (DAMP) molecules. High-mobility group box 1 protein (HMGB1) or amphoterin, which previously was considered to be only a nuclear factor, has been recently identified as a DAMP molecule. ...The modula …
These are collectively known as damage-associated molecular-pattern (DAMP) molecules. High-mobility group box 1 protein (HMGB1) or …
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