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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1976 4
1977 4
1978 7
1979 14
1980 8
1981 18
1982 8
1983 17
1984 19
1985 23
1986 14
1987 16
1988 16
1989 12
1990 23
1991 26
1992 22
1993 29
1994 52
1995 40
1996 45
1997 48
1998 45
1999 48
2000 55
2001 62
2002 65
2003 79
2004 105
2005 93
2006 119
2007 204
2008 235
2009 302
2010 334
2011 434
2012 488
2013 566
2014 611
2015 726
2016 727
2017 753
2018 820
2019 846
2020 594
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7,802 results
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Page 1
Extracellular HMGB1 as a therapeutic target in inflammatory diseases.
Andersson U, Yang H, Harris H. Andersson U, et al. Expert Opin Ther Targets. 2018 Mar;22(3):263-277. doi: 10.1080/14728222.2018.1439924. Epub 2018 Feb 15. Expert Opin Ther Targets. 2018. PMID: 29447008 Review.
High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. ...Therapeutic interventions to regulate intracellular HMGB1 biology must still awai …
High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly aft …
Anti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases.
Nishibori M, Mori S, Takahashi HK. Nishibori M, et al. J Pharmacol Sci. 2019 May;140(1):94-101. doi: 10.1016/j.jphs.2019.04.006. Epub 2019 May 4. J Pharmacol Sci. 2019. PMID: 31105025 Free article. Review.
High mobility group box-1 (HMGB1), a representative damage associated-molecular pattern (DAMP), has been reported to be involved in many inflammatory diseases. ...In this review, we summarize existing knowledge on the effects of anti-HMGB1 mAb on CNS and PNS …
High mobility group box-1 (HMGB1), a representative damage associated-molecular pattern (DAMP), has been reported to be involv …
[HMGB1 as a representative DAMP and anti-HMGB1 antibody therapy].
Nishibori M. Nishibori M. Nihon Yakurigaku Zasshi. 2018;151(1):4-8. doi: 10.1254/fpj.151.4. Nihon Yakurigaku Zasshi. 2018. PMID: 29321395 Japanese.
High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be involved in many inflammatory diseases. To validate HMGB1 as a target molecule of inflammatory diseases and to examine the effects of inh …
High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be invo …
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.
Andersson U, Yang H, Harris H. Andersson U, et al. Semin Immunol. 2018 Aug;38:40-48. doi: 10.1016/j.smim.2018.02.011. Epub 2018 Mar 9. Semin Immunol. 2018. PMID: 29530410 Review.
The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. The protein can be emitted to alert adjacent cells about endangered homeostasis of the HMG
The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity …
The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.
Yang H, Antoine DJ, Andersson U, Tracey KJ. Yang H, et al. J Leukoc Biol. 2013 Jun;93(6):865-73. doi: 10.1189/jlb.1212662. Epub 2013 Feb 27. J Leukoc Biol. 2013. PMID: 23446148 Free PMC article. Review.
HMGB1 contains three conserved redox-sensitive cysteines (C23, C45, and C106); modification of these cysteines determines the bioactivity of extracellular HMGB1. ...Lastly, post-translational acetylation of key lysine residues within NLSs of HMGB1 affects
HMGB1 contains three conserved redox-sensitive cysteines (C23, C45, and C106); modification of these cysteines determines the bioacti
Effects of mimicked acetylated HMGB1 on macrophages and dendritic cells.
Chen X, Xu Y, Xiong P, Tan Z, Gong F, Hou X, Zheng F. Chen X, et al. Mol Med Rep. 2018 Dec;18(6):5527-5535. doi: 10.3892/mmr.2018.9584. Epub 2018 Oct 24. Mol Med Rep. 2018. PMID: 30365069 Free PMC article.
Extracellular high mobility group box 1 (HMGB1) serves a critical role in inflammatory diseases. HMGB1 is released into the extracellular environment mainly by passive release from necrotic cells or active secretion from monocytes/macrophages following stimul …
Extracellular high mobility group box 1 (HMGB1) serves a critical role in inflammatory diseases. HMGB1 is released into …
Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1.
Lian YJ, Gong H, Wu TY, Su WJ, Zhang Y, Yang YY, Peng W, Zhang T, Zhou JR, Jiang CL, Wang YX. Lian YJ, et al. Brain Behav Immun. 2017 Jan;59:322-332. doi: 10.1016/j.bbi.2016.09.017. Epub 2016 Sep 16. Brain Behav Immun. 2017. PMID: 27647532
High mobility group box 1 (HMGB1) has been implicated as a key factor in several neuroinflammatory conditions. Our previous study suggested that the release of central HMGB1 acts as a late-phase mediator in lipopolysaccharide (LPS)-induced depression. ...Fr- …
High mobility group box 1 (HMGB1) has been implicated as a key factor in several neuroinflammatory conditions. Our previous st …
Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice.
Chen X, Ling Y, Wei Y, Tang J, Ren Y, Zhang B, Jiang F, Li H, Wang R, Wen W, Lv G, Wu M, Chen L, Li L, Wang H. Chen X, et al. FASEB J. 2018 May;32(5):2722-2734. doi: 10.1096/fj.201700875R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29298863
The expression and extracellular release of HMGB1 was rapidly and dramatically induced by saturated palmitic acid in vitro. HFD-induced inflammatory response and liver function impairment were both mitigated after the inhibition of endogenous HMGB1 by neutralizing a …
The expression and extracellular release of HMGB1 was rapidly and dramatically induced by saturated palmitic acid in vitro. HFD-induc …
Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.
Coleman LG Jr, Zou J, Crews FT. Coleman LG Jr, et al. J Neuroinflammation. 2017 Jan 25;14(1):22. doi: 10.1186/s12974-017-0799-4. J Neuroinflammation. 2017. PMID: 28118842 Free PMC article.
Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). ...CONCLUSIONS: Our results identify that ethanol induces neuroimmune p …
Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while red …
Time-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseases.
Umahara T, Uchihara T, Hirokawa K, Hirao K, Shimizu S, Hashimoto T, Terasi H, Hanyu H. Umahara T, et al. Histol Histopathol. 2018 Feb;33(2):215-222. doi: 10.14670/HH-11-914. Epub 2017 Jul 3. Histol Histopathol. 2018. PMID: 28671243
High mobility group box 1 protein (HMGB1) has multiple functions, including the maintenance of nucleosomes and the regulation of gene transcription. ...In an animal model, HMGB1 neutralization ameliorates brain infarction, there is an early release of HMGB
High mobility group box 1 protein (HMGB1) has multiple functions, including the maintenance of nucleosomes and the regulation …
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