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Loss of Metabolic Flexibility in the Failing Heart.
Karwi QG, Uddin GM, Ho KL, Lopaschuk GD. Karwi QG, et al. Among authors: ho kl. Front Cardiovasc Med. 2018 Jun 6;5:68. doi: 10.3389/fcvm.2018.00068. eCollection 2018. Front Cardiovasc Med. 2018. PMID: 29928647 Free PMC article. Review.
Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.
Verma S, Rawat S, Ho KL, Wagg CS, Zhang L, Teoh H, Dyck JE, Uddin GM, Oudit GY, Mayoux E, Lehrke M, Marx N, Lopaschuk GD. Verma S, et al. Among authors: ho kl. JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587. doi: 10.1016/j.jacbts.2018.07.006. eCollection 2018 Oct. JACC Basic Transl Sci. 2018. PMID: 30456329 Free PMC article.
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.
Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, Oudit GY, Lopaschuk GD. Uddin GM, et al. Among authors: ho kl. Cardiovasc Diabetol. 2019 Jul 5;18(1):86. doi: 10.1186/s12933-019-0892-3. Cardiovasc Diabetol. 2019. PMID: 31277657 Free PMC article.
Ketone metabolism in the failing heart.
Lopaschuk GD, Karwi QG, Ho KL, Pherwani S, Ketema EB. Lopaschuk GD, et al. Among authors: ho kl. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158813. doi: 10.1016/j.bbalip.2020.158813. Epub 2020 Sep 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32920139 Review.
Insulin directly stimulates mitochondrial glucose oxidation in the heart.
Karwi QG, Wagg CS, Altamimi TR, Uddin GM, Ho KL, Darwesh AM, Seubert JM, Lopaschuk GD. Karwi QG, et al. Among authors: ho kl. Cardiovasc Diabetol. 2020 Dec 7;19(1):207. doi: 10.1186/s12933-020-01177-3. Cardiovasc Diabetol. 2020. PMID: 33287820 Free PMC article.
Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation.
Greenwell AA, Gopal K, Altamimi TR, Saed CT, Wang F, Tabatabaei Dakhili SA, Ho KL, Zhang L, Eaton F, Kruger J, Al Batran R, Lopaschuk GD, Oudit GY, Ussher JR. Greenwell AA, et al. Among authors: ho kl. Am J Physiol Heart Circ Physiol. 2021 Jun 1;320(6):H2255-H2269. doi: 10.1152/ajpheart.00873.2020. Epub 2021 Apr 30. Am J Physiol Heart Circ Physiol. 2021. PMID: 33929899 Free article.
319 results