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Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins.
Hobbs S, Jitrapakdee S, Wallace JC. Hobbs S, et al. Biochem Biophys Res Commun. 1998 Nov 18;252(2):368-72. doi: 10.1006/bbrc.1998.9646. Biochem Biophys Res Commun. 1998. PMID: 9826536
Overexpression of BclXL in a human ovarian carcinoma cell line: paradoxic effects on chemosensitivity in vitro versus in vivo.
Rogers PM, Beale PJ, Al-Moundhri M, Boxall F, Patterson L, Valenti M, Raynaud F, Hobbs S, Johnston S, Kelland LR. Rogers PM, et al. Among authors: hobbs s. Int J Cancer. 2002 Feb 20;97(6):858-63. doi: 10.1002/ijc.10132. Int J Cancer. 2002. PMID: 11857368
High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance.
Cocker HA, Hobbs SM, Tiffin N, Pritchard-Jones K, Pinkerton CR, Kelland LR. Cocker HA, et al. Among authors: hobbs sm. Br J Cancer. 2001 Nov 30;85(11):1746-52. doi: 10.1054/bjoc.2001.2145. Br J Cancer. 2001. PMID: 11742497 Free PMC article.
Expression of recombinant antibody fusion proteins in E. coli.
Hobbs SM. Hobbs SM. Methods Mol Biol. 1998;80:419-25. doi: 10.1007/978-1-59259-257-9_42. Methods Mol Biol. 1998. PMID: 9664398 No abstract available.
Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Sharp SY, et al. Among authors: hobbs s. Mol Pharmacol. 2000 Nov;58(5):1146-55. doi: 10.1124/mol.58.5.1146. Mol Pharmacol. 2000. PMID: 11040064
Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Holmes JL, Sharp SY, Hobbs S, Workman P. Holmes JL, et al. Among authors: hobbs s. Cancer Res. 2008 Feb 15;68(4):1188-97. doi: 10.1158/0008-5472.CAN-07-3268. Cancer Res. 2008. PMID: 18281495
Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line.
Pestell KE, Hobbs SM, Titley JC, Kelland LR, Walton MI. Pestell KE, et al. Among authors: hobbs sm. Mol Pharmacol. 2000 Mar;57(3):503-11. doi: 10.1124/mol.57.3.503. Mol Pharmacol. 2000. PMID: 10692490
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Bailey SM, Knox RJ, Hobbs SM, Jenkins TC, Mauger AB, Melton RG, Burke PJ, Connors TA, Hart IR. Bailey SM, et al. Among authors: hobbs sm. Gene Ther. 1996 Dec;3(12):1143-50. Gene Ther. 1996. PMID: 8986441
Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines.
Sharp SY, Smith V, Hobbs S, Kelland LR. Sharp SY, et al. Among authors: hobbs s. Br J Cancer. 1998 Jul;78(2):175-80. doi: 10.1038/bjc.1998.461. Br J Cancer. 1998. PMID: 9683290 Free PMC article.
Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.
Cowen RL, Patterson AV, Telfer BA, Airley RE, Hobbs S, Phillips RM, Jaffar M, Stratford IJ, Williams KJ. Cowen RL, et al. Among authors: hobbs s. Mol Cancer Ther. 2003 Sep;2(9):901-9. Mol Cancer Ther. 2003. PMID: 14555709
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