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Focal adhesion kinase signaling and function in pancreatic cancer.
Ucar DA, Dang LH, Hochwald SN. Ucar DA, et al. Front Biosci (Elite Ed). 2011 Jan 1;3:750-6. doi: 10.2741/e283. Front Biosci (Elite Ed). 2011. PMID: 21196348 Review.
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. Chen M, et al. Mol Cancer Ther. 2012 Feb;11(2):370-82. doi: 10.1158/1535-7163.MCT-11-0458. Epub 2011 Dec 27. Mol Cancer Ther. 2012. PMID: 22203734 Free PMC article.
Nuclear factor-kappa B is upregulated in colorectal cancer.
Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland EM 3rd, Mackay S. Lind DS, et al. Surgery. 2001 Aug;130(2):363-9. doi: 10.1067/msy.2001.116672. Surgery. 2001. PMID: 11490372
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Ucar DA, et al. Cell Cycle. 2012 Sep 1;11(17):3250-9. doi: 10.4161/cc.21611. Epub 2012 Aug 16. Cell Cycle. 2012. PMID: 22894899 Free PMC article.
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya VM. Hochwald SN, et al. Cell Cycle. 2009 Aug;8(15):2435-43. doi: 10.4161/cc.8.15.9145. Epub 2009 Aug 1. Cell Cycle. 2009. PMID: 19571674 Free PMC article.
Targeting of the protein interaction site between FAK and IGF-1R.
Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN. Zheng D, et al. Biochem Biophys Res Commun. 2009 Oct 16;388(2):301-5. doi: 10.1016/j.bbrc.2009.07.156. Epub 2009 Aug 5. Biochem Biophys Res Commun. 2009. PMID: 19664602 Free PMC article.
Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo.
Ucar DA, Magis AT, He DH, Lawrence NJ, Sebti SM, Kurenova E, Zajac-Kaye M, Zhang J, Hochwald SN. Ucar DA, et al. Anticancer Agents Med Chem. 2013 May;13(4):595-602. doi: 10.2174/1871520611313040009. Anticancer Agents Med Chem. 2013. PMID: 23272972 Free PMC article.
A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts.
Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG, Hochwald SN. Zheng D, et al. Mol Carcinog. 2010 Feb;49(2):200-9. doi: 10.1002/mc.20590. Mol Carcinog. 2010. PMID: 19885860 Free PMC article.
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