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Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Yang B, Hodgkinson A, Millward BA, Demaine AG. Yang B, et al. Among authors: hodgkinson a. J Diabetes Complications. 2010 Nov-Dec;24(6):404-8. doi: 10.1016/j.jdiacomp.2009.09.005. Epub 2009 Nov 6. J Diabetes Complications. 2010. PMID: 19896870
Three SNPs, rs761745 (C/T), and rs2232873 (A/G) in the promoter and rs1055271 (C/G) in the 3'-untranslated were genotyped commercially. ...Patients with T1D had a decreased frequency of the combination genotypes of CC (rs761745), GG (rs2232873) and GC (rs1055271) co …
Three SNPs, rs761745 (C/T), and rs2232873 (A/G) in the promoter and rs1055271 (C/G) in the 3'-untranslated were genotyped commerciall …
Protective effect of statin therapy on connective tissue growth factor induction by diabetes in vivo and high glucose in vitro.
Yang B, Hodgkinson AD, Shaw NA, Millward BA, Demaine AG. Yang B, et al. Among authors: hodgkinson ad. Growth Factors. 2013 Dec;31(6):199-208. doi: 10.3109/08977194.2013.852189. Epub 2013 Nov 5. Growth Factors. 2013. PMID: 24192280
In conclusion, our in vitro study suggests that statin may have a renal-protective effect through the inhibition of CTGF expression. Urine CTGF may be a good marker for the prediction of diabetic nephropathy....
In conclusion, our in vitro study suggests that statin may have a renal-protective effect through the inhibition of CTGF expression. …
Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy.
Yang B, Hodgkinson AD, Oates PJ, Kwon HM, Millward BA, Demaine AG. Yang B, et al. Among authors: hodgkinson ad. Diabetes. 2006 May;55(5):1450-5. doi: 10.2337/db05-1260. Diabetes. 2006. PMID: 16644704
Peripheral blood mononuclear cells (PBMCs) were isolated from the following subjects: 44 Caucasoid patients with type 1 diabetes, of whom 26 had nephropathy and 18 had no nephropathy after a diabetes duration of 20 years, and 13 normal healthy control subjects. ...
Peripheral blood mononuclear cells (PBMCs) were isolated from the following subjects: 44 Caucasoid patients with type 1 diabetes, of whom 26 …
Glucose transporter polymorphisms are associated with clear-cell renal carcinoma.
Page T, Hodgkinson AD, Ollerenshaw M, Hammonds JC, Demaine AG. Page T, et al. Among authors: hodgkinson ad. Cancer Genet Cytogenet. 2005 Dec;163(2):151-5. doi: 10.1016/j.cancergencyto.2005.07.004. Cancer Genet Cytogenet. 2005. PMID: 16337858
GLUT1 is a downstream target of Hypoxia-inducible factor (HIF-1alpha), a mediator of hypoxia-controlled angiogenesis. In this study, we examine the allelic frequency of polymorphisms in the promoter and the second intron of the GLUT1 gene. ...There was a high …
GLUT1 is a downstream target of Hypoxia-inducible factor (HIF-1alpha), a mediator of hypoxia-controlled angiogenesis. In this …
The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy.
Hodgkinson AD, Bartlett T, Oates PJ, Millward BA, Demaine AG. Hodgkinson AD, et al. Diabetes. 2003 Mar;52(3):846-51. doi: 10.2337/diabetes.52.3.846. Diabetes. 2003. PMID: 12606529

Under HG, there was a twofold increase in the expression of CAT, CuZnSOD, and GPX mRNA in the patients without complications and the control subjects versus patients with nephropathy (P < 0.0001), and MnSOD did not change in any of the groups. ...There was a high

Under HG, there was a twofold increase in the expression of CAT, CuZnSOD, and GPX mRNA in the patients without complications and the …
Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes.
Hodgkinson AD, Millward BA, Demaine AG. Hodgkinson AD, et al. Diabetes Care. 2003 Nov;26(11):3111-5. doi: 10.2337/diacare.26.11.3111. Diabetes Care. 2003. PMID: 14578247
OBJECTIVE: Increased production of reactive oxygen species (ROS) in diabetes is thought to play a major role in the pathogenesis of diabetic microvascular complications such as nephropathy and retinopathy. ...The p22 subunit is polymorphic with a C242T variant that …
OBJECTIVE: Increased production of reactive oxygen species (ROS) in diabetes is thought to play a major role in the pathogenesis of d …
Is inflammation a common retinal-renal-nerve pathogenic link in diabetes?
Kaul K, Hodgkinson A, Tarr JM, Kohner EM, Chibber R. Kaul K, et al. Among authors: hodgkinson a. Curr Diabetes Rev. 2010 Sep;6(5):294-303. doi: 10.2174/157339910793360851. Curr Diabetes Rev. 2010. PMID: 20594163 Review.
The global diabetes burden is predicted to rise to 380 million by 2025 and would present itself as a major health challenge. ...Here we discuss low-grade inflammation as a common retinal-renal-nerve pathogenic link in patients with Type 1 and Type 2 diabetes. ...
The global diabetes burden is predicted to rise to 380 million by 2025 and would present itself as a major health challenge. ...Here …
High glucose induction of DNA-binding activity of the transcription factor NFkappaB in patients with diabetic nephropathy.
Yang B, Hodgkinson A, Oates PJ, Millward BA, Demaine AG. Yang B, et al. Among authors: hodgkinson a. Biochim Biophys Acta. 2008 May;1782(5):295-302. doi: 10.1016/j.bbadis.2008.01.009. Epub 2008 Feb 15. Biochim Biophys Acta. 2008. PMID: 18325349
ARI induced a substantially greater decrease of NFkappaB binding activities in the nephropaths compared to the uncomplicated subjects (0.58+/-0.06 vs. 0.79+/-0.06, p=0.032). ...
ARI induced a substantially greater decrease of NFkappaB binding activities in the nephropaths compared to the uncomplicated subjects …
Hydrogen sulfide induces heme oxygenase-1 in human kidney cells.
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A. D'Araio E, et al. Among authors: hodgkinson a. Acta Diabetol. 2014 Feb;51(1):155-7. doi: 10.1007/s00592-013-0501-y. Epub 2013 Jul 13. Acta Diabetol. 2014. PMID: 23852531
Hydrogen sulfide (H2S) has been shown to have a potential protective role in a number of disease states including diabetes and various kidney disorders; however, the mechanisms involved are still unclear. ...These results suggest that H2S has a role in the re …
Hydrogen sulfide (H2S) has been shown to have a potential protective role in a number of disease states including diabetes and …
AKR1B10 is induced by hyperglycaemia and lipopolysaccharide in patients with diabetic nephropathy.
Shaw N, Yang B, Millward A, Demaine A, Hodgkinson A. Shaw N, et al. Among authors: hodgkinson a. Cell Stress Chaperones. 2014 Mar;19(2):281-7. doi: 10.1007/s12192-013-0455-6. Epub 2013 Aug 23. Cell Stress Chaperones. 2014. PMID: 23975544 Free PMC article.
The objective of this study was to investigate whether AKR1B10 has a role in diabetic nephropathy (DN) by investigating its response to high glucose and inflammation, both of which have been associated with the development and progression of DN. ...Under high glucose and L …
The objective of this study was to investigate whether AKR1B10 has a role in diabetic nephropathy (DN) by investigating its response …
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