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Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients.
Rittig SM, Haentschel M, Weimer KJ, Heine A, Muller MR, Brugger W, Horger MS, Maksimovic O, Stenzl A, Hoerr I, Rammensee HG, Holderried TA, Kanz L, Pascolo S, Brossart P. Rittig SM, et al. Among authors: hoerr i. Mol Ther. 2011 May;19(5):990-9. doi: 10.1038/mt.2010.289. Epub 2010 Dec 28. Mol Ther. 2011. PMID: 21189474 Free PMC article. Clinical Trial.
Characterization of the ribonuclease activity on the skin surface.
Probst J, Brechtel S, Scheel B, Hoerr I, Jung G, Rammensee HG, Pascolo S. Probst J, et al. Among authors: hoerr i. Genet Vaccines Ther. 2006 May 29;4:4. doi: 10.1186/1479-0556-4-4. Genet Vaccines Ther. 2006. PMID: 16732888 Free PMC article.
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