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Divergent homeo box proteins recognize similar DNA sequences in Drosophila.
Hoey T, Levine M. Hoey T, et al. Nature. 1988 Apr 28;332(6167):858-61. doi: 10.1038/332858a0. Nature. 1988. PMID: 2895896
The en binding sites contain at least one copy of a 10-base pair consensus sequence: T-C-A-A-T-T-A-A-A-T. In contrast, the 5' eve binding sites are relatively G-C rich and do not share obvious similarities with the 10-base pair consensus sequence assoc …
The en binding sites contain at least one copy of a 10-base pair consensus sequence: T-C-A-A-T-T-A-A-A-T. In con …
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Lim JS, et al. Among authors: hoey t. Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10. Nature. 2017. PMID: 28489825 Free PMC article.
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses.
Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH. Hoey T, et al. EMBO J. 2003 Aug 15;22(16):4237-48. doi: 10.1093/emboj/cdg393. EMBO J. 2003. PMID: 12912921 Free PMC article.
Our results indicate that T-cell-specific expression of Stat4alpha or Stat4beta can mediate many aspects of IL-12 signaling including the differentiation of Th1 cells. ...
Our results indicate that T-cell-specific expression of Stat4alpha or Stat4beta can mediate many aspects of IL-12 signaling including …
STAT4 requires the N-terminal domain for efficient phosphorylation.
Chang HC, Zhang S, Oldham I, Naeger L, Hoey T, Kaplan MH. Chang HC, et al. J Biol Chem. 2003 Aug 22;278(34):32471-7. doi: 10.1074/jbc.M302776200. Epub 2003 Jun 12. J Biol Chem. 2003. PMID: 12805384
Whereas full-length STAT4 rescued IL-12 responsiveness, T lymphocytes expressing the STAT4 N-terminal mutant failed to proliferate in response to IL-12 and had limited Th1 cell development as evidenced by minimal interferon-gamma production. Deletion of the N-terminal doma …
Whereas full-length STAT4 rescued IL-12 responsiveness, T lymphocytes expressing the STAT4 N-terminal mutant failed to proliferate in …
The transcription factor NFAT4 is involved in the generation and survival of T cells.
Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH. Oukka M, et al. Immunity. 1998 Sep;9(3):295-304. doi: 10.1016/s1074-7613(00)80612-3. Immunity. 1998. PMID: 9768749
Mice lacking NFAT4 have impaired development of CD4 and CD8 SP thymocytes and peripheral T cells as well as hyperactivation of peripheral T cells. ...NFAT4 thus plays an important role in the successful generation and survival of T cells....
Mice lacking NFAT4 have impaired development of CD4 and CD8 SP thymocytes and peripheral T cells as well as hyperactivation of periph …
The transcription factor NF-ATc is essential for cardiac valve formation.
Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. Ranger AM, et al. Nature. 1998 Mar 12;392(6672):186-90. doi: 10.1038/32426. Nature. 1998. PMID: 9515964
Nuclear factor of activated T cells (NF-AT) is the name of a family of four related transcription factors that may be needed for cytokine gene expression in activated lymphocytes. ...As in T cells, nuclear translocation of NF-ATc in cardiac endothelial cells is cont …
Nuclear factor of activated T cells (NF-AT) is the name of a family of four related transcription factors that may be needed for cyto …
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Ranger AM, et al. Immunity. 1998 Jan;8(1):125-34. doi: 10.1016/s1074-7613(00)80465-3. Immunity. 1998. PMID: 9462518
Furthermore, NF-ATc deficiency impaired T lymphocyte activation and secretion of IL-4. B lymphocytes displayed reduced proliferation and a selective loss of IL-4-driven immunoglobulin isotypes both in vivo and in vitro. Our data demonstrate that NF-ATc is essential for the …
Furthermore, NF-ATc deficiency impaired T lymphocyte activation and secretion of IL-4. B lymphocytes displayed reduced proliferation …
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.
Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH. Hodge MR, et al. Immunity. 1996 Apr;4(4):397-405. doi: 10.1016/s1074-7613(00)80253-8. Immunity. 1996. PMID: 8612134
NF-ATp is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In this study, we show that mice with a null mutation in the NF-ATp gene have splenomegaly with hyperproliferation of both B and T cell …
NF-ATp is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In …
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