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NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.
Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, Grant EP, Coyle AJ, Misaghi A, Hoffman HM, Gallo RL. Yamasaki K, et al. Among authors: hoffman hm. J Biol Chem. 2009 May 8;284(19):12762-71. doi: 10.1074/jbc.M806084200. Epub 2009 Mar 3. J Biol Chem. 2009. PMID: 19258328 Free PMC article.
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.
Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM. Lamkanfi M, et al. Among authors: hoffman hm. J Cell Biol. 2009 Oct 5;187(1):61-70. doi: 10.1083/jcb.200903124. J Cell Biol. 2009. PMID: 19805629 Free PMC article.
Autoinflammation: translating mechanism to therapy.
Doherty TA, Brydges SD, Hoffman HM. Doherty TA, et al. Among authors: hoffman hm. J Leukoc Biol. 2011 Jul;90(1):37-47. doi: 10.1189/jlb.1110616. Epub 2011 Feb 17. J Leukoc Biol. 2011. PMID: 21330349 Free PMC article. Review.
157 results