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CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease.
Greidinger EL, Zang YJ, Jaimes K, Martinez L, Nassiri M, Hoffman RW. Greidinger EL, et al. Among authors: hoffman rw. J Immunol. 2008 Jun 15;180(12):8444-54. doi: 10.4049/jimmunol.180.12.8444. J Immunol. 2008. PMID: 18523312 Free PMC article.
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