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Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, Draetta G. Hoffmann I, et al. EMBO J. 1993 Jan;12(1):53-63. EMBO J. 1993. PMID: 8428594 Free PMC article.
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.
Chang J, Cizmecioglu O, Hoffmann I, Rhee K. Chang J, et al. Among authors: hoffmann i. EMBO J. 2010 Jul 21;29(14):2395-406. doi: 10.1038/emboj.2010.118. Epub 2010 Jun 8. EMBO J. 2010. PMID: 20531387 Free PMC article.
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.
Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R. Tumurbaatar I, et al. Among authors: hoffmann i. PLoS One. 2011 Feb 17;6(2):e14711. doi: 10.1371/journal.pone.0014711. PLoS One. 2011. PMID: 21379580 Free PMC article.
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I. Timofeev O, et al. Among authors: hoffmann i. J Biol Chem. 2010 May 28;285(22):16978-90. doi: 10.1074/jbc.M109.096552. Epub 2010 Apr 1. J Biol Chem. 2010. PMID: 20360007 Free PMC article.
Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases.
Timofeev O, Cizmecioglu O, Hu E, Orlik T, Hoffmann I. Timofeev O, et al. Among authors: hoffmann i. FEBS Lett. 2009 Feb 18;583(4):841-7. doi: 10.1016/j.febslet.2009.01.044. Epub 2009 Feb 2. FEBS Lett. 2009. PMID: 19192479
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.
Hassepass I, Voit R, Hoffmann I. Hassepass I, et al. Among authors: hoffmann i. J Biol Chem. 2003 Aug 8;278(32):29824-9. doi: 10.1074/jbc.M302704200. Epub 2003 May 20. J Biol Chem. 2003. PMID: 12759351
Assaying Cdc25 phosphatase activity.
Hassepass I, Hoffmann I. Hassepass I, et al. Among authors: hoffmann i. Methods Mol Biol. 2004;281:153-62. doi: 10.1385/1-59259-811-0:153. Methods Mol Biol. 2004. PMID: 15220527
Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.
Blomberg I, Hoffmann I. Blomberg I, et al. Among authors: hoffmann i. Mol Cell Biol. 1999 Sep;19(9):6183-94. doi: 10.1128/mcb.19.9.6183. Mol Cell Biol. 1999. PMID: 10454565 Free PMC article.
The cdc25B phosphatase is essential for the G2/M phase transition in human cells.
Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W, Hoffmann I. Lammer C, et al. Among authors: hoffmann i. J Cell Sci. 1998 Aug;111 ( Pt 16):2445-53. J Cell Sci. 1998. PMID: 9683638
Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester.
Barth H, Hoffmann I, Klein S, Kaszkin M, Richards J, Kinzel V. Barth H, et al. Among authors: hoffmann i. J Cell Physiol. 1996 Sep;168(3):589-99. doi: 10.1002/(SICI)1097-4652(199609)168:3<589::AID-JCP11>3.0.CO;2-V. J Cell Physiol. 1996. PMID: 8816913
The kinase activity of active MPF is not inhibited; rather, the conversion of pre-MPF to MPF, i.e., the activating dephosphorylation of p34cdc2, at tyrosine is rapidly blocked (Barth and Kinzel, 1994, Exp. ...The phosphatase responsible, cdc25-C, is activated by phosphoryl …
The kinase activity of active MPF is not inhibited; rather, the conversion of pre-MPF to MPF, i.e., the activating dephosphorylation …
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