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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
1930 1
1937 1
1947 1
1948 4
1950 2
1951 2
1952 5
1953 2
1954 2
1956 1
1957 2
1959 1
1960 2
1962 2
1963 3
1964 5
1965 2
1966 2
1967 2
1968 3
1969 2
1970 7
1971 1
1972 2
1973 3
1974 2
1975 8
1976 4
1977 3
1978 13
1979 10
1980 12
1981 16
1982 19
1983 9
1984 14
1985 9
1986 9
1987 12
1988 12
1989 12
1990 16
1991 16
1992 13
1993 11
1994 7
1995 16
1996 18
1997 24
1998 16
1999 11
2000 20
2001 20
2002 15
2003 11
2004 21
2005 29
2006 33
2007 36
2008 40
2009 56
2010 61
2011 68
2012 71
2013 60
2014 76
2015 75
2016 74
2017 79
2018 83
2019 94
2020 12
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1,287 results
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1,287 articles found by citation matching

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Page 1
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sims R, et al. Nat Genet 2017. Among authors: Hoffmann P. PMID 28714976 Free PMC article.
In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. ...We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10(-10), odds ratio (OR) = 0.68, minor allele frequency (MAF)(cases) = 0.0059, MAF(controls) = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10(-10), OR = 1.43, MAF(cases) = 0.011, MAF(controls) = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10(-14), OR = 1.67, MAF(cases) = 0.0143, MAF(controls) = 0.0089), a known susceptibility gene for Alzheimer's disease. ...

In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed geno

Selenium, Selenoproteins, and Immunity
Avery JC and Hoffmann PR. Nutrients 2018 - Review. PMID 30200430 Free PMC article.
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle BW, et al. Nat Genet 2019. Among authors: Hoffmann P. PMID 30820047 Free PMC article.
Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10(-7)), indicating that additional rare variants remain to be identified. ...
Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10(-7)), indicating that additional rare variants r …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall CR, et al. Nat Genet 2017. Among authors: Hoffmann P. PMID 27869829 Free PMC article.
A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10(-5)). ...
A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10(-15)), which persisted after excluding …
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Mitchell JS, et al. Nat Commun 2016. Among authors: Hoffmann P. PMID 27363682 Free PMC article.
We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (rs9372120, P=9.09 × 10(-15)), 7q36.1 (rs7781265, P=9.71 × 10(-9)), 8q24.21 (rs1948915, P=4.20 × 10(-11)), 9p21.3 (rs2811710, P=1.72 × 10(-13)), 10p12.1 (rs2790457, P=1.77 × 10(-8)), 16q23.1 (rs7193541, P=5.00 × 10(-12)) and 20q13.13 (rs6066835, P=1.36 × 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. ...
We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (rs9372120, P=9. …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Walters RK, et al. Nat Neurosci 2018. Among authors: Hoffmann P. PMID 30482948 Free PMC article.
Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10(-13)) and African ancestries (rs2066702; P = 2.2 × 10(-9)). ...
Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10(-13)) a …
1,287 results
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