Hofman FM - Search Results

1

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.

Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schönthal AH. Pyrko P, et al. Among authors: hofman fm. Mol Cancer. 2006 May 18;5:19. doi: 10.1186/1476-4598-5-19. Mol Cancer. 2006. PMID: 16707021 Free PMC article.

2

The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.

Chen TC, Wadsten P, Su S, Rawlinson N, Hofman FM, Hill CK, Schönthal AH. Chen TC, et al. Among authors: hofman fm. Cancer Biol Ther. 2002 May-Jun;1(3):268-76. doi: 10.4161/cbt.80. Cancer Biol Ther. 2002. PMID: 12432276

3

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Cancer Biol Ther. 2005 May;4(5):571-82. doi: 10.4161/cbt.4.5.1699. Epub 2005 May 5. Cancer Biol Ther. 2005. PMID: 15846081

4

Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib.

Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Blood. 2005 Dec 15;106(13):4330-8. doi: 10.1182/blood-2005-07-2819. Epub 2005 Aug 25. Blood. 2005. PMID: 16123214 Free article.

5

Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.

Kardosh A, Soriano N, Pyrko P, Liu YT, Jabbour M, Hofman FM, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. J Biomed Sci. 2007 Sep;14(5):647-62. doi: 10.1007/s11373-007-9173-3. Epub 2007 Apr 18. J Biomed Sci. 2007. PMID: 17440835

6

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS. Pyrko P, et al. Among authors: hofman fm. Cancer Res. 2007 Oct 15;67(20):9809-16. doi: 10.1158/0008-5472.CAN-07-0625. Cancer Res. 2007. PMID: 17942911

7

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs.

Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. Schönthal AH, et al. Among authors: hofman fm. Expert Opin Investig Drugs. 2008 Feb;17(2):197-208. doi: 10.1517/13543784.17.2.197. Expert Opin Investig Drugs. 2008. PMID: 18230053 Review.

8

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.

Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Cancer Res. 2008 Feb 1;68(3):843-51. doi: 10.1158/0008-5472.CAN-07-5555. Cancer Res. 2008. PMID: 18245486

9

Increased survivin expression confers chemoresistance to tumor-associated endothelial cells.

Virrey JJ, Guan S, Li W, Schönthal AH, Chen TC, Hofman FM. Virrey JJ, et al. Among authors: hofman fm. Am J Pathol. 2008 Aug;173(2):575-85. doi: 10.2353/ajpath.2008.071079. Epub 2008 Jul 3. Am J Pathol. 2008. PMID: 18599610 Free PMC article.

10

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.

Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman FM, Lee AS. Virrey JJ, et al. Among authors: hofman fm. Mol Cancer Res. 2008 Aug;6(8):1268-75. doi: 10.1158/1541-7786.MCR-08-0060. Mol Cancer Res. 2008. PMID: 18708359 Free PMC article.

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