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Protein kinase C isozymes as potential targets for anticancer therapy.
Hofmann J. Hofmann J. Curr Cancer Drug Targets. 2004 Mar;4(2):125-46. doi: 10.2174/1568009043481579. Curr Cancer Drug Targets. 2004. PMID: 15032665 Review.
Impact of PKCε downregulation on autophagy in glioblastoma cells.
Toton E, Romaniuk A, Konieczna N, Hofmann J, Barciszewski J, Rybczynska M. Toton E, et al. Among authors: hofmann j. BMC Cancer. 2018 Feb 13;18(1):185. doi: 10.1186/s12885-018-4095-1. BMC Cancer. 2018. PMID: 29439667 Free PMC article.
The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease.
Toton E, Lisiak N, Rubis B, Budzianowski J, Gruber P, Hofmann J, Rybczynska M. Toton E, et al. Among authors: hofmann j. Eur J Pharmacol. 2012 May 5;682(1-3):21-8. doi: 10.1016/j.ejphar.2012.02.020. Epub 2012 Feb 21. Eur J Pharmacol. 2012. PMID: 22381066 Free PMC article.
Signal transduction of constitutively active protein kinase C epsilon.
Garczarczyk D, Toton E, Biedermann V, Rosivatz E, Rechfeld F, Rybczynska M, Hofmann J. Garczarczyk D, et al. Among authors: hofmann j. Cell Signal. 2009 May;21(5):745-52. doi: 10.1016/j.cellsig.2009.01.017. Epub 2009 Jan 9. Cell Signal. 2009. PMID: 19168130
Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation.
Garczarczyk D, Szeker K, Galfi P, Csordas A, Hofmann J. Garczarczyk D, et al. Among authors: hofmann j. Chem Biol Interact. 2010 Apr 15;185(1):25-32. doi: 10.1016/j.cbi.2010.02.035. Epub 2010 Feb 25. Chem Biol Interact. 2010. PMID: 20188713 Free PMC article.
Barbituric acid derivative BAS 02104951 inhibits PKCε, PKCη, PKCε/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCε and η translocation in PC3 cells following TPA-induction.
Gruber P, Rechfeld F, Kirchmair J, Hauser N, Boehler M, Garczarczyk D, Langer T, Hofmann J. Gruber P, et al. Among authors: hofmann j. J Biochem. 2011 Mar;149(3):331-6. doi: 10.1093/jb/mvq147. Epub 2010 Dec 24. J Biochem. 2011. PMID: 21186251
Modulators of protein-protein interactions: novel approaches in targeting protein kinases and other pharmaceutically relevant biomolecules.
Rechfeld F, Gruber P, Hofmann J, Kirchmair J. Rechfeld F, et al. Among authors: hofmann j. Curr Top Med Chem. 2011;11(11):1305-19. doi: 10.2174/156802611795589610. Curr Top Med Chem. 2011. PMID: 21513500 Review.
Zapotin (5,6,2',6'-tetramethoxyflavone) Modulates the Crosstalk Between Autophagy and Apoptosis Pathways in Cancer Cells with Overexpressed Constitutively Active PKCϵ.
Toton E, Romaniuk A, Budzianowski J, Hofmann J, Rybczynska M. Toton E, et al. Among authors: hofmann j. Nutr Cancer. 2016;68(2):290-304. doi: 10.1080/01635581.2016.1134595. Epub 2016 Feb 4. Nutr Cancer. 2016. PMID: 26847268
Thienoquinolines as novel disruptors of the PKCε/RACK2 protein-protein interaction.
Rechfeld F, Gruber P, Kirchmair J, Boehler M, Hauser N, Hechenberger G, Garczarczyk D, Lapa GB, Preobrazhenskaya MN, Goekjian P, Langer T, Hofmann J. Rechfeld F, et al. Among authors: hofmann j. J Med Chem. 2014 Apr 24;57(8):3235-46. doi: 10.1021/jm401605c. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24712764 Free PMC article.
N-benzoxazol-2-yl-N'-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential.
Hofmann J, Easmon J, Puerstinger G, Heinisch G, Jenny M, Shtil AA, Hermann M, Condorelli DF, Sciré S, Musumarra G. Hofmann J, et al. Invest New Drugs. 2009 Jun;27(3):189-202. doi: 10.1007/s10637-008-9156-x. Epub 2008 Jul 9. Invest New Drugs. 2009. PMID: 18612590
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