Hofmann KP - Search Results

1

Effect of channel mutations on the uptake and release of the retinal ligand in opsin.

Piechnick R, Ritter E, Hildebrand PW, Ernst OP, Scheerer P, Hofmann KP, Heck M. Piechnick R, et al. Among authors: hofmann kp. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5247-52. doi: 10.1073/pnas.1117268109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431612 Free PMC article.

2

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.

Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Fritze O, et al. Among authors: hofmann kp. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2290-5. doi: 10.1073/pnas.0435715100. Epub 2003 Feb 24. Proc Natl Acad Sci U S A. 2003. PMID: 12601165 Free PMC article.

3

Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit.

Ernst OP, Gramse V, Kolbe M, Hofmann KP, Heck M. Ernst OP, et al. Among authors: hofmann kp. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10859-64. doi: 10.1073/pnas.0701967104. Epub 2007 Jun 19. Proc Natl Acad Sci U S A. 2007. PMID: 17578920 Free PMC article.

4

Sequence of late molecular events in the activation of rhodopsin.

Knierim B, Hofmann KP, Ernst OP, Hubbell WL. Knierim B, et al. Among authors: hofmann kp. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20290-5. doi: 10.1073/pnas.0710393104. Epub 2007 Dec 11. Proc Natl Acad Sci U S A. 2007. PMID: 18077356 Free PMC article.

5

Crystal structure of the ligand-free G-protein-coupled receptor opsin.

Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP. Park JH, et al. Among authors: hofmann kp. Nature. 2008 Jul 10;454(7201):183-7. doi: 10.1038/nature07063. Epub 2008 Jun 18. Nature. 2008. PMID: 18563085

6

Crystal structure of opsin in its G-protein-interacting conformation.

Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP. Scheerer P, et al. Among authors: hofmann kp. Nature. 2008 Sep 25;455(7212):497-502. doi: 10.1038/nature07330. Nature. 2008. PMID: 18818650

7

A ligand channel through the G protein coupled receptor opsin.

Hildebrand PW, Scheerer P, Park JH, Choe HW, Piechnick R, Ernst OP, Hofmann KP, Heck M. Hildebrand PW, et al. Among authors: hofmann kp. PLoS One. 2009;4(2):e4382. doi: 10.1371/journal.pone.0004382. Epub 2009 Feb 5. PLoS One. 2009. PMID: 19194506 Free PMC article.

8

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface.

Scheerer P, Heck M, Goede A, Park JH, Choe HW, Ernst OP, Hofmann KP, Hildebrand PW. Scheerer P, et al. Among authors: hofmann kp. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10660-5. doi: 10.1073/pnas.0900072106. Epub 2009 Jun 17. Proc Natl Acad Sci U S A. 2009. PMID: 19541654 Free PMC article.

9

A G protein-coupled receptor at work: the rhodopsin model.

Hofmann KP, Scheerer P, Hildebrand PW, Choe HW, Park JH, Heck M, Ernst OP. Hofmann KP, et al. Trends Biochem Sci. 2009 Nov;34(11):540-52. doi: 10.1016/j.tibs.2009.07.005. Epub 2009 Oct 21. Trends Biochem Sci. 2009. PMID: 19836958 Review.

10

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin.

Sommer ME, Hofmann KP, Heck M. Sommer ME, et al. Among authors: hofmann kp. Nat Commun. 2012;3:995. doi: 10.1038/ncomms2000. Nat Commun. 2012. PMID: 22871814 Free PMC article.

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