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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG. Godoy P, et al. Among authors: hofmann u. Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23. Arch Toxicol. 2016. PMID: 27339419 Free PMC article.
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
Fendt R, Hofmann U, Schneider ARP, Schaeffeler E, Burghaus R, Yilmaz A, Blank LM, Kerb R, Lippert J, Schlender JF, Schwab M, Kuepfer L. Fendt R, et al. Among authors: hofmann u. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):782-793. doi: 10.1002/psp4.12646. Epub 2021 Jun 26. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34053199 Free PMC article. Clinical Trial.
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.
Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, Brosch M, von Schoenfels W, Erhart W, Schuppert A, Block M, Schaeffeler E, Boehmer G, Goerlitz L, Hoecker J, Lippert J, Kerb R, Hampe J, Kuepfer L, Schwab M. Krauss M, et al. Among authors: hofmann u. NPJ Syst Biol Appl. 2017 Mar 28;3:11. doi: 10.1038/s41540-017-0012-5. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28649438 Free PMC article.
512 results