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Radical causes of cancer.
Hussain SP, Hofseth LJ, Harris CC. Hussain SP, et al. Nat Rev Cancer. 2003 Apr;3(4):276-85. doi: 10.1038/nrc1046. Nat Rev Cancer. 2003. PMID: 12671666 Review.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC. Sohn JJ, et al. PLoS One. 2012;7(9):e44156. doi: 10.1371/journal.pone.0044156. Epub 2012 Sep 6. PLoS One. 2012. PMID: 22970173 Free PMC article.
Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.
Ying L, Marino J, Hussain SP, Khan MA, You S, Hofseth AB, Trivers GE, Dixon DA, Harris CC, Hofseth LJ. Ying L, et al. Cancer Res. 2005 Oct 15;65(20):9132-6. doi: 10.1158/0008-5472.CAN-05-1358. Cancer Res. 2005. PMID: 16230367
Nitric oxide is a key component in inflammation-accelerated tumorigenesis.
Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC. Hussain SP, et al. Cancer Res. 2008 Sep 1;68(17):7130-6. doi: 10.1158/0008-5472.CAN-08-0410. Cancer Res. 2008. PMID: 18757428 Free PMC article.
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.
Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC. Hofseth LJ, et al. J Clin Invest. 2003 Dec;112(12):1887-94. doi: 10.1172/JCI19757. J Clin Invest. 2003. PMID: 14679184 Free PMC article.
Inflammation and IGF-I activate the Akt pathway in breast cancer.
Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, Ambs S. Prueitt RL, et al. Int J Cancer. 2007 Feb 15;120(4):796-805. doi: 10.1002/ijc.22336. Int J Cancer. 2007. PMID: 17096325
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