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The insider's guide to leukocyte integrin signalling and function.
Hogg N, Patzak I, Willenbrock F. Hogg N, et al. Nat Rev Immunol. 2011 Jun;11(6):416-26. doi: 10.1038/nri2986. Epub 2011 May 20. Nat Rev Immunol. 2011. PMID: 21597477 Review.
Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
Ramsay AG, Evans R, Kiaii S, Svensson L, Hogg N, Gribben JG. Ramsay AG, et al. Among authors: hogg n. Blood. 2013 Apr 4;121(14):2704-14. doi: 10.1182/blood-2012-08-448332. Epub 2013 Jan 16. Blood. 2013. PMID: 23325833 Free PMC article.
SHARPIN regulates uropod detachment in migrating lymphocytes.
Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J. Pouwels J, et al. Among authors: hogg n. Cell Rep. 2013 Nov 14;5(3):619-28. doi: 10.1016/j.celrep.2013.10.011. Epub 2013 Nov 7. Cell Rep. 2013. PMID: 24210817 Free PMC article.
The Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling.
Svensson L, Stanley P, Willenbrock F, Hogg N. Svensson L, et al. Among authors: hogg n. PLoS One. 2012;7(6):e38517. doi: 10.1371/journal.pone.0038517. Epub 2012 Jun 11. PLoS One. 2012. PMID: 22701657 Free PMC article.
Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro.
McDowall A, Svensson L, Stanley P, Patzak I, Chakravarty P, Howarth K, Sabnis H, Briones M, Hogg N. McDowall A, et al. Among authors: hogg n. Blood. 2010 Jun 10;115(23):4834-42. doi: 10.1182/blood-2009-08-238709. Epub 2010 Mar 31. Blood. 2010. PMID: 20357244
Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.
Miertzschke M, Stanley P, Bunney TD, Rodrigues-Lima F, Hogg N, Katan M. Miertzschke M, et al. Among authors: hogg n. J Biol Chem. 2007 Oct 19;282(42):30629-42. doi: 10.1074/jbc.M704361200. Epub 2007 Aug 23. J Biol Chem. 2007. PMID: 17716979
Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.
Stanley P, Smith A, McDowall A, Nicol A, Zicha D, Hogg N. Stanley P, et al. Among authors: hogg n. EMBO J. 2008 Jan 9;27(1):62-75. doi: 10.1038/sj.emboj.7601959. Epub 2007 Dec 13. EMBO J. 2008. PMID: 18079697 Free PMC article.
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice.
Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, Bolomini-Vittori M, Korf-Klingebiel M, Napp LC, Hansen B, Kanwischer A, Bavendiek U, Beutel G, Hapke M, Sauer MG, Laudanna C, Hogg N, Vestweber D, Wollert KC. Kempf T, et al. Among authors: hogg n. Nat Med. 2011 May;17(5):581-8. doi: 10.1038/nm.2354. Epub 2011 Apr 24. Nat Med. 2011. PMID: 21516086
Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.
De Filippo K, Henderson RB, Laschinger M, Hogg N. De Filippo K, et al. Among authors: hogg n. J Immunol. 2008 Mar 15;180(6):4308-15. doi: 10.4049/jimmunol.180.6.4308. J Immunol. 2008. PMID: 18322244
Nicotine has suppressive effects on dendritic cell function.
Hogg N. Hogg N. Immunology. 2003 Jul;109(3):329-30. doi: 10.1046/j.1365-2567.2003.01685.x. Immunology. 2003. PMID: 12807476 Free PMC article. No abstract available.
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