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An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies.
Schönfeld D, Matschiner G, Chatwell L, Trentmann S, Gille H, Hülsmeyer M, Brown N, Kaye PM, Schlehuber S, Hohlbaum AM, Skerra A. Schönfeld D, et al. Among authors: hohlbaum am. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8198-203. doi: 10.1073/pnas.0813399106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416843 Free PMC article.
A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity.
Olwill SA, Joffroy C, Gille H, Vigna E, Matschiner G, Allersdorfer A, Lunde BM, Jaworski J, Burrows JF, Chiriaco C, Christian HJ, Hülsmeyer M, Trentmann S, Jensen K, Hohlbaum AM, Audoly L. Olwill SA, et al. Among authors: hohlbaum am. Mol Cancer Ther. 2013 Nov;12(11):2459-71. doi: 10.1158/1535-7163.MCT-13-0318. Epub 2013 Sep 3. Mol Cancer Ther. 2013. PMID: 24002935
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.
Hohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL. Hohlbaum AM, et al. Br J Pharmacol. 2018 Apr;175(7):1054-1065. doi: 10.1111/bph.14143. Epub 2018 Feb 23. Br J Pharmacol. 2018. PMID: 29329501 Free PMC article.
Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma.
Matschiner G, Fitzgerald MF, Moebius U, Hohlbaum AM, Gille H, Jensen K, Kirchfeld K, Rattenstetter B, Laforge A, Bel Aiba RS, Ciccotosto J, Nyugen H, Foster ML, Snouwaert JN, Nguyen M, Koller BH, Matis L, Anderson GP, Olwill SA. Matschiner G, et al. Among authors: hohlbaum am. J Allergy Clin Immunol. 2023 Apr;151(4):966-975. doi: 10.1016/j.jaci.2022.12.815. Epub 2022 Dec 30. J Allergy Clin Immunol. 2023. PMID: 36592703 Free article.
Engineered human lipocalin as an antibody mimetic: application to analysis of the small peptide hormone hepcidin.
Grebenchtchikov N, Geurts-Moespot AJ, Trentmann S, Andersen N, Bel Aiba RS, Allersdorfer A, Laarakkers CM, Sweep FC, Tjalsma H, Hohlbaum AM, Swinkels DW. Grebenchtchikov N, et al. Among authors: hohlbaum am. Clin Chem. 2014 Jun;60(6):897-9. doi: 10.1373/clinchem.2014.221671. Epub 2014 Apr 7. Clin Chem. 2014. PMID: 24710076 Free article. No abstract available.
BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics.
Hall AP, Tepper JS, Boyle MH, Cary MG, Flandre TG, Piaia A, Tarnow I, Macri NP, Freke MC, Nikula KJ, Paul GR, Cauvin A, Gregori M, Haworth R, Naylor S, Price M, Robinson IN, Allen A, Gelzleichter T, Hohlbaum AM, Manetz S, Wolfreys A, Colman K, Fleurance R, Jones D, Mukaratirwa S. Hall AP, et al. Among authors: hohlbaum am. Toxicol Pathol. 2021 Feb;49(2):235-260. doi: 10.1177/0192623320976094. Epub 2021 Jan 18. Toxicol Pathol. 2021. PMID: 33455525 Review.
18 results