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XIAP: apoptotic brake and promising therapeutic target.
Holcik M, Gibson H, Korneluk RG. Holcik M, et al. Apoptosis. 2001 Aug;6(4):253-61. doi: 10.1023/a:1011379307472. Apoptosis. 2001. PMID: 11445667 Review.
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation.
Holcik M, Korneluk RG. Holcik M, et al. Mol Cell Biol. 2000 Jul;20(13):4648-57. doi: 10.1128/mcb.20.13.4648-4657.2000. Mol Cell Biol. 2000. PMID: 10848591 Free PMC article.
Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.
Liwak U, Thakor N, Jordan LE, Roy R, Lewis SM, Pardo OE, Seckl M, Holcik M. Liwak U, et al. Among authors: holcik m. Mol Cell Biol. 2012 May;32(10):1818-29. doi: 10.1128/MCB.06317-11. Epub 2012 Mar 19. Mol Cell Biol. 2012. PMID: 22431522 Free PMC article.
Cap-independent regulation of gene expression in apoptosis.
Graber TE, Holcik M. Graber TE, et al. Among authors: holcik m. Mol Biosyst. 2007 Dec;3(12):825-34. doi: 10.1039/b708867a. Epub 2007 Sep 18. Mol Biosyst. 2007. PMID: 18000559 Review.
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.
Conte D, Holcik M, Lefebvre CA, Lacasse E, Picketts DJ, Wright KE, Korneluk RG. Conte D, et al. Among authors: holcik m. Mol Cell Biol. 2006 Jan;26(2):699-708. doi: 10.1128/MCB.26.2.699-708.2006. Mol Cell Biol. 2006. PMID: 16382159 Free PMC article.
Translational control in stress and apoptosis.
Holcik M, Sonenberg N. Holcik M, et al. Nat Rev Mol Cell Biol. 2005 Apr;6(4):318-27. doi: 10.1038/nrm1618. Nat Rev Mol Cell Biol. 2005. PMID: 15803138 Review.
Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis.
Holcík M. Holcík M. Expert Opin Ther Targets. 2004 Jun;8(3):241-53. doi: 10.1517/14728222.8.3.241. Expert Opin Ther Targets. 2004. PMID: 15161430 Review.
Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.
Warnakulasuriyarachchi D, Cerquozzi S, Cheung HH, Holcík M. Warnakulasuriyarachchi D, et al. Among authors: holcik m. J Biol Chem. 2004 Apr 23;279(17):17148-57. doi: 10.1074/jbc.M308737200. Epub 2004 Feb 11. J Biol Chem. 2004. PMID: 14960583
The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.
Holcík M, Gordon BW, Korneluk RG. Holcík M, et al. Mol Cell Biol. 2003 Jan;23(1):280-8. doi: 10.1128/mcb.23.1.280-288.2003. Mol Cell Biol. 2003. PMID: 12482981 Free PMC article.
Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.
Nevins TA, Harder ZM, Korneluk RG, Holcík M. Nevins TA, et al. Among authors: holcik m. J Biol Chem. 2003 Feb 7;278(6):3572-9. doi: 10.1074/jbc.M206781200. Epub 2002 Nov 27. J Biol Chem. 2003. PMID: 12458215
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