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A peroxisome proliferator-activated receptor-alpha (PPARalpha) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARalpha: implications for species differences in responses to peroxisome proliferators.
Tugwood JD, Holden PR, James NH, Prince RA, Roberts RA. Tugwood JD, et al. Among authors: holden pr. Arch Toxicol. 1998 Feb;72(3):169-77. doi: 10.1007/s002040050483. Arch Toxicol. 1998. PMID: 9520140
Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression.
Holden PR, James NH, Brooks AN, Roberts RA, Kimber I, Pennie WD. Holden PR, et al. J Biochem Mol Toxicol. 2000;14(5):283-90. doi: 10.1002/1099-0461(2000)14:5<283::AID-JBT7>3.0.CO;2-S. J Biochem Mol Toxicol. 2000. PMID: 10970000
Tumour necrosis factor alpha (TNFalpha): role in suppression of apoptosis by the peroxisome proliferator nafenopin.
Holden PR, Hasmall SC, James NH, West DR, Brindle RD, Gonzalez FJ, Peters JM, Roberts RA. Holden PR, et al. Cell Mol Biol (Noisy-le-grand). 2000 Feb;46(1):29-39. Cell Mol Biol (Noisy-le-grand). 2000. PMID: 10726969
Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha.
Roberts RA, James NH, Hasmall SC, Holden PR, Lambe K, Macdonald N, West D, Woodyatt NJ, Whitcome D. Roberts RA, et al. Among authors: holden pr. Toxicol Lett. 2000 Mar 15;112-113:49-57. doi: 10.1016/s0378-4274(99)00243-x. Toxicol Lett. 2000. PMID: 10720712 Review.
Role for tumor necrosis factor alpha receptor 1 and interleukin-1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin.
West DA, James NH, Cosulich SC, Holden PR, Brindle R, Rolfe M, Roberts RA. West DA, et al. Among authors: holden pr. Hepatology. 1999 Dec;30(6):1417-24. doi: 10.1002/hep.510300612. Hepatology. 1999. PMID: 10573520
Addition of peroxisome proliferator-activated receptor alpha to guinea pig hepatocytes confers increased responsiveness to peroxisome proliferators.
Macdonald N, Holden PR, Roberts RA. Macdonald N, et al. Among authors: holden pr. Cancer Res. 1999 Oct 1;59(19):4776-80. Cancer Res. 1999. PMID: 10519382 Free article.
Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis.
James NH, Gill JH, Brindle R, Woodyatt NJ, Macdonald N, Rolfe M, Hasmall SC, Tugwood JD, Holden PR, Roberts RA. James NH, et al. Among authors: holden pr. Toxicol Lett. 1998 Dec 28;102-103:91-6. doi: 10.1016/s0378-4274(98)00291-4. Toxicol Lett. 1998. PMID: 10022238 Review.
Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences.
Holden PR, Tugwood JD. Holden PR, et al. J Mol Endocrinol. 1999 Feb;22(1):1-8. doi: 10.1677/jme.0.0220001. J Mol Endocrinol. 1999. PMID: 9924174 Review.
Immediate-early gene expression during regenerative and mitogen-induced liver growth in the rat.
Holden PR, Odum J, Soames AR, Foster JR, Elcombe CR, Tugwood JD. Holden PR, et al. J Biochem Mol Toxicol. 1998;12(2):79-82. doi: 10.1002/(sici)1099-0461(1998)12:2<79::aid-jbt2>;2-l. J Biochem Mol Toxicol. 1998. PMID: 9443064
Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37.
Vanden Heuvel JP, Holden P, Tugwood J, Ingle C, Yen W, Galjart N, Greenlee WF. Vanden Heuvel JP, et al. Among authors: holden p. Toxicol Appl Pharmacol. 1998 Sep;152(1):107-18. doi: 10.1006/taap.1998.8478. Toxicol Appl Pharmacol. 1998. PMID: 9772206
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